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  PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing

Fuchs, A., Torroba, M., & Kinkley, S. (2017). PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing. Transcription, 8(2), 106-112. doi:10.1080/21541264.2016.1274813.

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Transcription_Fuchs et al_2017.pdf (Publisher version), 487KB
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Transcription_Fuchs et al_2017.pdf
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© 2017 Taylor & Francis
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 Creators:
Fuchs, Alisa1, Author
Torroba, Marcos1, Author
Kinkley, Sarah1, Author              
Affiliations:
1Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              

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Free keywords: bivalency and H3K4me3, co-transcriptional splicing, PHF13, polycomb repressive complex 2 (PRC2), RNA polymerase II, RNA polymerase II pausing, SPOC1, transcriptional regulation
 Abstract: We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

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Language(s): eng - English
 Dates: 2016-12-162017-01-19
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1080/21541264.2016.1274813
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Title: Transcription
Source Genre: Journal
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Publ. Info: London : Taylor & Francis
Pages: 7 Volume / Issue: 8 (2) Sequence Number: - Start / End Page: 106 - 112 Identifier: -