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  Resting-state fMRI functional connectivity strength predicts local activity change in the dorsal cingulate cortex: A multi-target focused rTMS study

Feng, Z.-J., Deng, X.-P., Zhao, N., Jin, J., Yue, J., Hu, Y.-S., et al. (2021). Resting-state fMRI functional connectivity strength predicts local activity change in the dorsal cingulate cortex: A multi-target focused rTMS study. Cerebral Cortex. doi:10.1093/cercor/bhab380.

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 Creators:
Feng, Zi-Jian1, 2, 3, Author
Deng, Xin-Ping1, 2, 3, Author
Zhao, Na1, 2, 3, Author
Jin, Jing1, 2, 3, Author
Yue, Juan1, 2, 3, Author
Hu, Yun-Song1, 2, 3, Author
Jing, Ying1, 2, 3, Author
Wang, Hong-Xiao1, 2, 3, Author
Knösche, Thomas R.4, Author              
Zang, Yu-Feng1, 2, 3, Author
Wang, Jue5, Author
Affiliations:
1Center for Cognition and Brain Disorders, Clinical Medicine College, Hangzhou Normal University, China, ou_persistent22              
2Institute of Psychological Sciences, Hangzhou Normal University, China, ou_persistent22              
3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China, ou_persistent22              
4Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
5Institute of Sports Medicine and Health, Chengdu Sport University, China, ou_persistent22              

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Free keywords: RS-fMRI; Functional connectivity; Local activity; Multi-target focused; rTMS
 Abstract: Previous resting state functional magnetic resonance imaging (RS-fMRI) studies suggested that repetitive transcranial magnetic stimulation (rTMS) can modulate local activity in distant areas via functional connectivity (FC). A brain region has more than one connection with the superficial cortical areas. The current study proposed a multi-target focused rTMS protocol for indirectly stimulating a deep region, and to investigate 1) whether FC strength between stimulation targets (right middle frontal gyrus [rMFG] and right inferior parietal lobule [rIPL]) and effective region (dorsal anterior cingulate cortex [dACC]) can predict local activity changes of dACC and 2) whether multiple stimulation targets can focus on the dACC via FC. A total of 24 healthy participants received rTMS with two stimulation targets, both showing strong FC with the dACC. There were four rTMS conditions (>1 week apart, 10 Hz, 1800 pulses for each): rMFG-target, rIPL-target, Double-targets (900 pulses for each target), and Sham. The results failed to validate the multi-target focused rTMS hypothesis. But rMFG-target significantly decreased the local activity in the dACC. In addition, stronger dACC-rMFG FC was associated with a greater local activity change in the dACC. Future studies should use stronger FC to focus stimulation effects on the deep region.

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Language(s): eng - English
 Dates: 2021-09-212021-05-292021-09-222021-10-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhab380
Other: online ahead of print
PMID: 34689201
 Degree: -

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Project name : -
Grant ID : 81701776, 31471084, 82071537, and 81520108016
Funding program : -
Funding organization : National Natural Science Foundation of China
Project name : -
Grant ID : 2019B030335001
Funding program : -
Funding organization : Key Medical Discipline of Hangzhou

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440