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  Metabolic profile and metabolite analyses in extreme weight responders to gastric bypass surgery

Fries, C., Haange, S.-B., Rolle-Kampczyk, U., Till, A., Lammert, M., Medawar, E., et al. (2022). Metabolic profile and metabolite analyses in extreme weight responders to gastric bypass surgery. Metabolites, 12(5): 417. doi:10.3390/metabo12050417.

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 Creators:
Fries, Charlotte1, Author
Haange, Sven-Bastiaan2, Author
Rolle-Kampczyk, Ulrike2, Author
Till, Andreas1, Author
Lammert, Mathis3, Author
Medawar, Evelyn3, Author              
Dietrich, Arne4, Author
Horstmann, Annette3, 5, Author              
von Bergen, Martin2, 6, 7, Author
Fenske, Wiebke1, Author
Affiliations:
1Department of Endocrinology, Diabetes and Metabolism, University Hospital Bonn, Germany, ou_persistent22              
2Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research (UfZ), Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Visceral and Metabolic Surgery, University Hospital Leipzig, Germany, ou_persistent22              
5Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
6German Centre for Integrative Biodiversity Research (iDiv), Leipzig, Germany, ou_persistent22              
7Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Bile acids; Bariatric surgery; Roux-en-Y gastric bypass; Weight response; Gut microbiota
 Abstract: Background: Roux-en-Y gastric bypass (RYGB) surgery belongs to the most frequently performed surgical therapeutic strategies against adiposity and its comorbidities. However, outcome is limited in a substantial cohort of patients with inadequate primary weight loss or considerable weight regain. In this study, gut microbiota composition and systemically released metabolites were analyzed in a cohort of extreme weight responders after RYGB. Methods: Patients (n = 23) were categorized based on excess weight loss (EWL) at a minimum of two years after RYGB in a good responder (EWL 93 ± 4.3%) or a bad responder group (EWL 19.5 ± 13.3%) for evaluation of differences in metabolic outcome, eating behavior and gut microbiota taxonomy and metabolic activity. Results: Mean BMI was 47.2 ± 6.4 kg/m2 in the bad vs. 26.6 ± 1.2 kg/m2 in the good responder group (p = 0.0001). We found no difference in hunger and satiety sensation, in fasting or postprandial gut hormone release, or in gut microbiota composition between both groups. Differences in weight loss did not reflect in metabolic outcome after RYGB. While fecal and circulating metabolite analyses showed higher levels of propionate (p = 0.0001) in good and valerate (p = 0.04) in bad responders, respectively, conjugated primary and secondary bile acids were higher in good responders in the fasted (p = 0.03) and postprandial state (GCA, p = 0.02; GCDCA, p = 0.02; TCA, p = 0.01; TCDCA, p = 0.02; GDCA, p = 0.05; GUDCA, p = 0.04; TLCA, p = 0.04). Conclusions: Heterogenous weight loss response to RYGB surgery separates from patients’ metabolic outcome, and is linked to unique serum metabolite signatures post intervention. These findings suggest that the level of adiposity reduction alone is insufficient to assess the metabolic success of RYGB surgery, and that longitudinal metabolite profiling may eventually help us to identify markers that could predict individual adiposity response to surgery and guide patient selection and counseling.

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Language(s): eng - English
 Dates: 2022-04-262022-03-312022-04-292022-05-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/metabo12050417
PMID: 35629921
PMC: PMC9147451
 Degree: -

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Project name : -
Grant ID : TRR333/1, 450149205, 624808, 403224013, SFB 1382- A05
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01EO1501
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : 1052
Funding program : -
Funding organization : Collaborative Research Center (CRC)
Project name : -
Grant ID : NNF21OC0066551
Funding program : -
Funding organization : Novo Nordisk Foundation

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Title: Metabolites
Source Genre: Journal
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Publ. Info: MDPI AG
Pages: - Volume / Issue: 12 (5) Sequence Number: 417 Start / End Page: - Identifier: Other: 2218-1989
CoNE: https://pure.mpg.de/cone/journals/resource/2218-1989