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  Synthetic developmental biology: Engineering approaches to guide multicellular organization

Zarkesh, I., Ashtiani, M. K., Shiri, Z., Aran, S., Braun, T., & Baharvand, H. (2022). Synthetic developmental biology: Engineering approaches to guide multicellular organization. STEM CELL REPORTS, 17(4), 715-733. doi:10.1016/j.stemcr.2022.02.004.

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Genre: Journal Article

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 Creators:
Zarkesh, Ibrahim, Author
Ashtiani, Mohammad Kazemi, Author
Shiri, Zahra, Author
Aran, Saeideh, Author
Braun, Thomas1, Author              
Baharvand, Hossein, Author
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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 Abstract: Multicellular organisms of various complexities self-organize in nature. Organoids are in vitro 3D structures that display important aspects of the anatomy and physiology of their in vivo counterparts and that develop from pluripotent or tissue-specific stem cells through a self-organization process. In this review, we describe the multidisciplinary concept of "synthetic developmental biology"where engineering approaches are employed to guide multicellular organization in an experimental setting. We introduce a novel classification of engineering approaches based on the extent of microenvironmental manipulation applied to organoids. In the final section, we discuss how engineering tools might help overcome current limitations in organoid construction.

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 Dates: 2022-03-102022-04-12
 Publication Status: Published in print
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Title: STEM CELL REPORTS
Source Genre: Journal
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Pages: - Volume / Issue: 17 (4) Sequence Number: - Start / End Page: 715 - 733 Identifier: ISSN: 2213-6711