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  The chaperone Clusterin in neurodegeneration-friend or foe?

Yuste-Checa, P., Bracher, A., & Hartl, F. U. (2022). The chaperone Clusterin in neurodegeneration-friend or foe? Bioessays, e2100287. doi:10.1002/bies.202100287.

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 Creators:
Yuste-Checa, Patricia1, Author              
Bracher, Andreas1, Author              
Hartl, F. Ulrich1, Author              
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Free keywords: SINGLE-MOLECULE CHARACTERIZATION; GENOME-WIDE ASSOCIATION; AMYLOID BETA-PEPTIDE; ALZHEIMERS-DISEASE; EXTRACELLULAR CHAPERONE; CEREBROSPINAL-FLUID; PATHOLOGICAL TAU; APOLIPOPROTEIN-J; ALPHA-SYNUCLEIN; IN-VIVOBiochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Alzheimer's disease; Clusterin; extracellular chaperone; neurodegeneration; protein aggregation; tau; tauopathies;
 Abstract: Fibrillar protein aggregates are the pathological hallmark of a group of age-dependent neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates of the microtubule-associated protein Tau are observed in Alzheimer's disease and primary tauopathies. Tau pathology propagates from cell to cell in a prion-like process that is likely subject to modulation by extracellular chaperones such as Clusterin. We recently reported that Clusterin delayed Tau fibril formation but enhanced the activity of Tau oligomers to seed aggregation of endogenous Tau in a cellular model. In contrast, Clusterin inhibited the propagation of alpha-Synuclein aggregates associated with Parkinson's disease. These findings raise the possibility of a mechanistic link between Clusterin upregulation observed in Alzheimer's disease and the progression of Tau pathology. Here we review the diverse functions of Clusterin in the pathogenesis of neurodegenerative diseases, focusing on evidence that Clusterin may act either as a suppressor or enhancer of pathology.

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Language(s): eng - English
 Dates: 2022
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000791438900001
DOI: 10.1002/bies.202100287
 Degree: -

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Title: Bioessays
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Pages: - Volume / Issue: - Sequence Number: e2100287 Start / End Page: - Identifier: ISSN: 0265-9247