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  Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses

McCulloch, D.-E.-W., Knudsen, G. M., Barrett, F. S., Doss, M. K., Carhart-Harris, R. L., Rosas, F. E., et al. (2022). Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses. Neuroscience and Biobehavioral Reviews, 104689. doi:10.1016/j.neubiorev.2022.104689.

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McCulloch, Drummond E-Wen1, Author
Knudsen, Gitte Moos1, 2, Author
Barrett, Frederick Streeter3, 4, Author
Doss, Manoj K.3, Author
Carhart-Harris, Robin Lester5, 6, Author
Rosas, Fernando E.6, 7, 8, Author
Deco, Gustavo9, 10, 11, 12, 13, Author              
Kringelbach, Morten L.14, 15, 16, Author
Preller, Katrin H.17, Author
Ramaekers, Johannes G.18, Author
Mason, Natasha L.18, Author
Müller, Felix19, Author
Fisher, Patrick MacDonald1, Author
Affiliations:
1Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark, ou_persistent22              
2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, ou_persistent22              
3Department of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
4Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ou_persistent22              
5Weill Institute for Neurosciences, University of California, San Francisco, CA, USA, ou_persistent22              
6Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
7Data Science Institute, Imperial College London, United Kingdom, ou_persistent22              
8Centre for Complexity Science, Imperial College London, United Kingdom, ou_persistent22              
9Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
10Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
11Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
12Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
13School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
14Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
15Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
16Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
17Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Zurich, Switzerland, ou_persistent22              
18Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
19Department of Psychiatry, University of Basel, Switzerland, ou_persistent22              

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Free keywords: DMT; LSD; Ayahausca; Clinical; Entheogen; fMRI; Hallucinogen; Human; Neuroimaging; Psilocin; Psilocybin; Psychedelic; Replication; Resting-state; Serotonin
 Abstract: Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research articles published to date, based on the 17 unique studies evaluating psychedelic effects on rs-fMRI, focusing on methodological variation. Prominently, we observe that nearly all studies vary in data processing and analysis methodology, two datasets are the foundation of over half of the published literature, and there is lexical ambiguity in common outcome metric terminology. We offer guidelines for future studies that encourage coherence in the field. Psychedelic rs-fMRI will benefit from the development of novel methods that expand our understanding of the brain mechanisms mediating its intriguing effects; yet, this field is at a crossroads where we must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.

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Language(s): eng - English
 Dates: 2022-05-052021-10-122022-05-052022-05-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neubiorev.2022.104689
Other: online ahead of print
PMID: 35588933
 Degree: -

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Title: Neuroscience and Biobehavioral Reviews
Source Genre: Journal
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Publ. Info: New York [etc.] : Pergamon
Pages: - Volume / Issue: - Sequence Number: 104689 Start / End Page: - Identifier: ISSN: 0149-7634
CoNE: https://pure.mpg.de/cone/journals/resource/954928536106