English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres

Schmidt, H., & Knösche, T. R. (2022). Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres. Biological Cybernetics. doi:10.1007/s00422-022-00934-9.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Schmidt_2022.pdf (Publisher version), 2MB
Name:
Schmidt_2022.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Schmidt, Helmut1, 2, Author              
Knösche, Thomas R.1, 3, Author              
Affiliations:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
2Institute of Computer Science, The Czech Academy of Sciences, Prague, ou_persistent22              
3Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              

Content

show
hide
Free keywords: Ephaptic coupling; Peripheral nerves; Spike propagation; Synchronisation
 Abstract: Experimental and theoretical studies have shown that ephaptic coupling leads to the synchronisation and slowing down of spikes propagating along the axons within peripheral nerve bundles. However, the main focus thus far has been on a small number of identical axons, whereas realistic peripheral nerve bundles contain numerous axons with different diameters. Here, we present a computationally efficient spike propagation model, which captures the essential features of propagating spikes and their ephaptic interaction, and facilitates the theoretical investigation of spike volleys in large, heterogeneous fibre bundles. We first lay out the theoretical basis to describe how the spike in an active axon changes the membrane potential of a passive axon. These insights are then incorporated into the spike propagation model, which is calibrated with a biophysically realistic model based on Hodgkin-Huxley dynamics. The fully calibrated model is then applied to fibre bundles with a large number of axons and different types of axon diameter distributions. One key insight of this study is that the heterogeneity of the axonal diameters has a dispersive effect, and that a higher level of heterogeneity requires stronger ephaptic coupling to achieve full synchronisation between spikes.

Details

show
hide
Language(s): eng - English
 Dates: 2021-12-092022-04-182022-05-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00422-022-00934-9
Other: online ahead of print
PMID: 35538379
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biological Cybernetics
  Other : Biol. Cybern.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0340-1200
CoNE: https://pure.mpg.de/cone/journals/resource/954927549307