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  A unified 3D map of microscopic architecture and MRI of the human brain

Alkemade, A., Bazin, P.-L., Balesar, R., Pine, K., Kirilina, E., Möller, H. E., et al. (2022). A unified 3D map of microscopic architecture and MRI of the human brain. Science Advances, 8(17): eabj7892. doi:10.1126/sciadv.abj7892.

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 Creators:
Alkemade, Anneke1, Author
Bazin, Pierre-Louis1, 2, 3, Author              
Balesar, Rawien4, Author
Pine, Kerrin2, Author              
Kirilina, Evgeniya2, 5, Author              
Möller, Harald E.6, Author              
Trampel, Robert2, Author              
Kros, Johan M.7, Author
Keuken, Max C.1, Author
Bleys, Ronald L. A. W.8, Author
Swaab, Dick F.4, Author
Herrler, Andreas9, Author
Weiskopf, Nikolaus2, 10, 11, Author              
Forstmann, Birte U.1, Author
Affiliations:
1Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Department of Neuropsychiatric Disorders, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
5Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands, ou_persistent22              
8Department of Anatomy, University Medical Center Utrecht, the Netherlands, ou_persistent22              
9Department of Anatomy and Embryology, Maastricht University, the Netherlands, ou_persistent22              
10Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
11Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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 Abstract: We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.

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Language(s): eng - English
 Dates: 2022-04-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/sciadv.abj7892
Other: epub 2022
PMID: 35476433
PMC: PMC9045605
 Degree: -

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Project name : -
Grant ID : 864750, 616905
Funding program : Horizon 2020
Funding organization : European Research Council
Project name : -
Grant ID : 01EW1711A + B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Affiliations:
Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 8 (17) Sequence Number: eabj7892 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548