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  Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species

Real, F. M., Lao-Pérez, M., Burgos, M., Mundlos, S., Lupiáñez, D. G., Jiménez, R., et al. (2022). Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species. Journal of Experimental Zoology Part B-Molecular and Developmental Evolution, 2022: 14, pp. 1. doi:10.1002/jez.b.23142.

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JEZ-B_Real et al_2022.pdf (Publisher version), 3MB
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Real, Francisca M.1, Author              
Lao-Pérez, Miguel , Author
Burgos, Miguel , Author
Mundlos, Stefan1, Author              
Lupiáñez, Darío G., Author
Jiménez, Rafael, Author
Barrionuevo, Francisco J. , Author
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: cell adhesion, immune response,Microtus duodecimcostatus, seasonal reproduction, seasonaltestis regression,Talpa occidentalis, testis transcriptome
 Abstract: In species with seasonal breeding, male specimens undergo substantial testicularregression during the nonbreeding period of the year. However, the molecularmechanisms that control this biological process are largely unknown. Here, wereport a transcriptomic analysis on the Iberian mole,Talpa occidentalis, in which thedesquamation of live, nonapoptotic germ cells is the major cellular event responsiblefor testis regression. By comparing testes at different reproductive states (active,regressing, and inactive), we demonstrate that the molecular pathways controllingthe cell adhesion function in the seminiferous epithelium, such as the MAPK, ERK,and TGF‐βsignaling, are altered during the regression process. In addition, inactivetestes display a global upregulation of genes associated with immune response,indicating a selective loss of the“immune privilege”that normally operates insexually active testes. Interspecies comparative analyses using analogous data fromthe Mediterranean pine vole, a rodent species where testis regression is controlledby halting meiosis entry, revealed a common gene expression signature in theregressed testes of these two evolutionary distant species. Our study advances inthe knowledge of the molecular mechanisms associated to gonadal seasonalbreeding, highlighting the existence of a conserved transcriptional program of testisinvolution across mammalian clades.

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Language(s): eng - English
 Dates: 2022-04-092022-05-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/jez.b.23142
 Degree: -

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Title: Journal of Experimental Zoology Part B-Molecular and Developmental Evolution
  Other : J. Exp. Zool. Part B
Source Genre: Journal
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Publ. Info: Hoboken, N.J. : Wiley-Liss, Inc.
Pages: - Volume / Issue: 2022 Sequence Number: 14 Start / End Page: 1 Identifier: ISSN: 1552-5007
CoNE: https://pure.mpg.de/cone/journals/resource/954925413887