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  Whole‐brain dynamics differentiate among cisgender and transgender individuals

Uribe, C., Escrichs, A., Filippi, E., Sanz‐Perl, Y., Junque, C., Gomez‐Gil, E., et al. (2022). Whole‐brain dynamics differentiate among cisgender and transgender individuals. Human Brain Mapping. doi:10.1002/hbm.25905.

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 Creators:
Uribe, Carme1, 2, 3, Author
Escrichs, Anira4, Author
Filippi, Eleonora4, Author
Sanz‐Perl, Yonatan4, Author
Junque, Carme1, 2, Author
Gomez‐Gil, Esther5, Author
Kringelbach, Morten L.6, 7, 8, Author
Guillamon, Antonio9, Author
Deco, Gustavo4, 10, 11, 12, Author           
Affiliations:
1Institute of Neurosciences, University of Barcelona, Spain, ou_persistent22              
2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ou_persistent22              
3Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
4Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5Gender Unit, Hospital Clinic, Barcelona, Spain, ou_persistent22              
6Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
7Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
8Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
9Department of Psychobiology, Faculty of Psychology, Universidad Nacional de Educacion a Distancia, Madrid, Spain, ou_persistent22              
10Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
11Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
12Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Cisgender; Dynamical complexity; Ignition; Sex/gender differences; Transgender; Whole-brain dynamics
 Abstract: How the brain represents gender identity is largely unknown, but some neural differences have recently been discovered. We used an intrinsic ignition framework to investigate whether there are gender differences in the propagation of neural activity across the whole-brain and within resting-state networks. Studying 29 trans men and 17 trans women with gender incongruence, 22 cis women, and 19 cis men, we computed the capability of a given brain area in space to propagate activity to other areas (mean-ignition), and the variability across time for each brain area (node-metastability). We found that both measurements differentiated all groups across the whole brain. At the network level, we found that compared to the other groups, cis men showed higher mean-ignition of the dorsal attention network and node-metastability of the dorsal and ventral attention, executive control, and temporal parietal networks. We also found higher mean-ignition values in cis men than in cis women within the executive control network, but higher mean-ignition in cis women than cis men and trans men for the default mode. Node-metastability was higher in cis men than cis women in the somatomotor network, while both mean-ignition and node-metastability were higher for cis men than trans men in the limbic network. Finally, we computed correlations between these measurements and a body image satisfaction score. Trans men's dissatisfaction as well as cis men's and cis women's satisfaction toward their own body image were distinctively associated with specific networks in each group. Overall, the study of the whole-brain network dynamical complexity discriminates gender identity groups, functional dynamic approaches could help disentangle the complex nature of the gender dimension in the brain.

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Language(s): eng - English
 Dates: 2022-05-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25905
Other: online ahead of print
PMID: 35583382
 Degree: -

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Project name : -
Grant ID : 945539, 888692
Funding program : Horizon 2020
Funding organization : -
Project name : -
Grant ID : PGC2018-094919-B-C21, PID2019-105772GB
Funding program : -
Funding organization : Ministerio de Ciencia e Innovación

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686