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  Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Yamamoto, H., Spitzner, F., Takemuro, T., Buendia, V., Morante, C., Konno, T., et al. (submitted). Modular architecture facilitates noise-driven control of synchrony in neuronal networks.

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Yamamoto, H, Author
Spitzner, FP, Author
Takemuro, T, Author
Buendia, V1, Author           
Morante, C, Author
Konno, T, Author
Sato, S, Author
Hirano-Iwata, A, Author
Priesemann, V, Author
Muñoz, MA, Author
Zierenberg, J, Author
Soriano, J, Author
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              

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 Abstract: Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands is by flexibly switching between synchronous and less synchronous states. Understanding how complex synchronization patterns are controlled by the interaction of network architecture and external perturbations is thus a central challenge in neuroscience, but the mechanisms behind such interactions remain elusive. Here, we utilise precision neuroengineering to manipulate cultured neuronal networks and show that a modular architecture facilitates desynchronization upon asynchronous stimulation, making external noise a control parameter of synchrony. Using spiking neuron models, we then demonstrate that external noise can reduce the level of available synaptic resources, which make intermodular interactions more stochastic and thereby facilitates the breakdown of synchrony. Finally, the phenomenology of stochastic intermodular interactions is formulated into a mesoscopic model that incorporates a state-dependent gating mechanism for signal propagation. Taken together, our results demonstrate a network mechanism by which asynchronous inputs tune the inherent dynamical state in structured networks of excitable units.

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 Dates: 2022-05
 Publication Status: Submitted
 Pages: -
 Publishing info: -
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 Rev. Type: -
 Identifiers: DOI: 10.48550/arXiv.2205.10563
 Degree: -

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