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  Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain

Wang, Y., Royer, J., Park, B.-y., Vos de Wael, R., Larivière, S., Tavakol, S., et al. (2022). Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain. Cerebral Cortex. doi:10.1093/cercor/bhac172.

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Wang, Yezhou1, Author
Royer, Jessica1, Author
Park, Bo-yong1, 2, 3, Author
Vos de Wael, Reinder1, Author
Larivière, Sara1, Author
Tavakol, Shahin1, Author
Rodriguez-Cruces, Raul1, Author
Paquola, Casey1, 4, Author
Hong, Seok-Jun3, 5, Author
Margulies, Daniel S.6, Author              
Smallwood, Jonathan7, Author              
Valk, Sofie L.4, 8, 9, Author              
Evans, Alan C.1, Author
Bernhardt, Boris C.1, Author              
1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
2Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22              
3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
6Cognitive Neuroanatomy Lab, Integrative Neuroscience and Cognition Centre, University of Paris, France, ou_persistent22              
7Department of Psychology, Queen’s University, Kingston, ON, Canada, ou_persistent22              
8Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
9Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              


Free keywords: Connectome; Cortical gradients; Cortical microstructure; Functional connectivity; Neuroimaging
 Abstract: Background: Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry. Methods: We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections. Results: Analysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range connections, while transmodal association systems hosted distributed, long-range connections. Meta-analytical decoding suggested that this topographical difference mirrored shifts in cognitive function, from perception/action towards emotional/social processing. Analysis of myelin-sensitive in vivo MRI as well as postmortem histology and transcriptomics datasets established that gradients in functional connectivity distance are paralleled by those present in cortical microarchitecture. Notably, long-range connections were found to link spatially remote regions of association cortex with an unexpectedly similar microarchitecture. Conclusions: By mapping covarying topographies of long-range functional connections and cortical microcircuits, the current work provides insights into structure-function relations in human neocortex.


Language(s): eng - English
 Dates: 2022-03-302021-11-162022-04-012022-05-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhac172
Other: online ahead of print
PMID: 35596951
 Degree: -



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Project name : -
Grant ID : NRF-2021R1F1A1052303
Funding program : -
Funding organization : National Research Foundation of Korea
Project name : -
Grant ID : 2020-0-01389
Funding program : -
Funding organization : Institute for Information and Communications Technology Planning and Evaluation
Project name : -
Grant ID : 2021-0-02068
Funding program : -
Funding organization : Artificial Intelligence Convergence Research Center, Inha University
Project name : -
Grant ID : 2022-0-00448
Funding program : -
Funding organization : Artificial Intelligence Innovation Hub
Project name : -
Grant ID : IBS-R015-D1
Funding program : -
Funding organization : Institute for Basic Science

Source 1

Title: Cerebral Cortex
Source Genre: Journal
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440