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  Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain

Wang, Y., Royer, J., Park, B.-y., Vos de Wael, R., Larivière, S., Tavakol, S., et al. (2023). Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain. Cerebral Cortex, 33(5), 1782-1798. doi:10.1093/cercor/bhac172.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-8462-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-6C1D-9
Genre: Journal Article

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Locator:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977370/ (Any fulltext)
Description:
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OA-Status:
Green

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 Creators:
Wang, Yezhou1, Author
Royer, Jessica1, Author
Park, Bo-yong1, 2, 3, Author
Vos de Wael, Reinder1, Author
Larivière, Sara1, Author
Tavakol, Shahin1, Author
Rodriguez-Cruces, Raul1, Author
Paquola, Casey1, 4, Author
Hong, Seok-Jun3, 5, Author
Margulies, Daniel S.6, Author           
Smallwood, Jonathan7, Author           
Valk, Sofie L.4, 8, 9, Author           
Evans, Alan C.1, Author
Bernhardt, Boris C.1, Author           
Affiliations:
1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
2Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22              
3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
6Cognitive Neuroanatomy Lab, Integrative Neuroscience and Cognition Centre, University of Paris, France, ou_persistent22              
7Department of Psychology, Queen’s University, Kingston, ON, Canada, ou_persistent22              
8Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
9Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              

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Free keywords: Connectome; Cortical gradients; Cortical microstructure; Functional connectivity; Neuroimaging
 Abstract:

Background: Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry.

Methods: We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections.

Results: Analysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range connections, while transmodal association systems hosted distributed, long-range connections. Meta-analytical decoding suggested that this topographical difference mirrored shifts in cognitive function, from perception/action towards emotional/social processing. Analysis of myelin-sensitive in vivo MRI as well as postmortem histology and transcriptomics datasets established that gradients in functional connectivity distance are paralleled by those present in cortical microarchitecture. Notably, long-range connections were found to link spatially remote regions of association cortex with an unexpectedly similar microarchitecture.

Conclusions: By mapping covarying topographies of long-range functional connections and cortical microcircuits, the current work provides insights into structure-function relations in human neocortex.

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Language(s): eng - English
 Dates: 2022-03-302021-11-162022-04-012022-05-222023-02-20
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhac172
PMID: 35596951
PMC: PMC9977370
 Degree: -

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Project name : -
Grant ID : NRF-2021R1F1A1052303
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Funding organization : National Research Foundation of Korea
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Grant ID : 2020-0-01389
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Funding organization : Institute for Information and Communications Technology Planning and Evaluation
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Grant ID : 2021-0-02068
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Funding organization : Artificial Intelligence Convergence Research Center, Inha University
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Grant ID : 2022-0-00448
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Funding organization : Artificial Intelligence Innovation Hub
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Grant ID : IBS-R015-D1
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Funding organization : Institute for Basic Science
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Funding organization : Richard and Ann Sievers award
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Funding organization : Max Planck Society
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Grant ID : 1304413
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Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
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Grant ID : CIHR FDN154298
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Grant ID : NI17-039
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Funding organization : SickKids Foundation
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Funding organization : Azrieli Center for Autism Research
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Funding organization : BrainCanada
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Funding organization : Canada Research Chairs
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Grant ID : 1U54MH091657
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Funding organization : Human Connectome Project, WU-Minn Consortium
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Funding organization : NIH Institutes and Centers
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Funding organization : McDonnell Center for Systems Neuroscience at Washington University
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Funding organization : Canadian Open Neuroscience Platform (CONP) fellowship

Source 1

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 33 (5) Sequence Number: - Start / End Page: 1782 - 1798 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440