Long-range functional connections mirror and link microarchitectural and 
cognitive hierarchies in the human brain

Wang, Yezhou; Royer, Jessica; Park, Bo-yong; Vos de Wael, Reinder; Larivière, Sara; Tavakol, Shahin; Rodriguez-Cruces, Raul; Paquola, Casey; Hong, Seok-Jun; Margulies, Daniel S.; Smallwood, Jonathan; Valk, Sofie L.; Evans, Alan C.; Bernhardt, Boris C.

doi:10.1093/cercor/bhac172

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Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain

Wang, Y., Royer, J., Park, B.-y., Vos de Wael, R., Larivière, S., Tavakol, S., et al. (2023). Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain. Cerebral Cortex, 33(5), 1782-1798. doi:10.1093/cercor/bhac172.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-8462-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-6C1D-9

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977370/ (beliebiger Volltext) Open Access Grün

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Wang, Yezhou¹, Autor
Royer, Jessica¹, Autor
Park, Bo-yong^{1, 2, 3}, Autor
Vos de Wael, Reinder¹, Autor
Larivière, Sara¹, Autor
Tavakol, Shahin¹, Autor
Rodriguez-Cruces, Raul¹, Autor
Paquola, Casey^{1, 4}, Autor
Hong, Seok-Jun^{3, 5}, Autor
Margulies, Daniel S.⁶, Autor
Smallwood, Jonathan⁷, Autor
Valk, Sofie L.^{4, 8, 9}, Autor
Evans, Alan C.¹, Autor
Bernhardt, Boris C.¹, Autor

Affiliations:
1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22
2Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22
3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea, ou_persistent22
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22
5Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22
6Cognitive Neuroanatomy Lab, Integrative Neuroscience and Cognition Centre, University of Paris, France, ou_persistent22
7Department of Psychology, Queen’s University, Kingston, ON, Canada, ou_persistent22
8Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264
9Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22

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Schlagwörter: Connectome; Cortical gradients; Cortical microstructure; Functional connectivity; Neuroimaging

Zusammenfassung:

Background: Higher-order cognition is hypothesized to be implemented via distributed cortical networks that are linked via long-range connections. However, it is unknown how computational advantages of long-range connections reflect cortical microstructure and microcircuitry.

Methods: We investigated this question by (i) profiling long-range cortical connectivity using resting-state functional magnetic resonance imaging (MRI) and cortico-cortical geodesic distance mapping, (ii) assessing how long-range connections reflect local brain microarchitecture, and (iii) examining the microarchitectural similarity of regions connected through long-range connections.

Results: Analysis of 2 independent datasets indicated that sensory/motor areas had more clustered short-range connections, while transmodal association systems hosted distributed, long-range connections. Meta-analytical decoding suggested that this topographical difference mirrored shifts in cognitive function, from perception/action towards emotional/social processing. Analysis of myelin-sensitive in vivo MRI as well as postmortem histology and transcriptomics datasets established that gradients in functional connectivity distance are paralleled by those present in cortical microarchitecture. Notably, long-range connections were found to link spatially remote regions of association cortex with an unexpectedly similar microarchitecture.

Conclusions: By mapping covarying topographies of long-range functional connections and cortical microcircuits, the current work provides insights into structure-function relations in human neocortex.

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Sprache(n): eng - English

Datum: Geändert: 2022-03-30Eingereicht: 2021-11-16Angenommen: 2022-04-01Online veröffentlicht: 2022-05-22Erschienen: 2023-02-20

Publikationsstatus: Erschienen

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Identifikatoren: DOI: 10.1093/cercor/bhac172
PMID: 35596951
PMC: PMC9977370

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Grant ID : NRF-2021R1F1A1052303

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Förderorganisation : National Research Foundation of Korea

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Grant ID : 2020-0-01389

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Förderorganisation : Institute for Information and Communications Technology Planning and Evaluation

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Grant ID : 2021-0-02068

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Förderorganisation : Artificial Intelligence Convergence Research Center, Inha University

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Förderorganisation : Artificial Intelligence Innovation Hub

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Förderorganisation : Institute for Basic Science

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Förderorganisation : Richard and Ann Sievers award

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Förderorganisation : Max Planck Society

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Förderorganisation : Natural Sciences and Engineering Research Council of Canada (NSERC)

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Förderorganisation : Canadian Institutes of Health Research (CIHR)

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Grant ID : NI17-039

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Förderorganisation : SickKids Foundation

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Förderorganisation : Azrieli Center for Autism Research

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Förderorganisation : Canada Research Chairs

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Förderorganisation : Human Connectome Project, WU-Minn Consortium

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Förderorganisation : NIH Institutes and Centers

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Förderorganisation : McDonnell Center for Systems Neuroscience at Washington University

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Förderorganisation : Canadian Open Neuroscience Platform (CONP) fellowship

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Titel: Cerebral Cortex

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: New York, NY : Oxford University Press

Seiten: - Band / Heft: 33 (5) Artikelnummer: - Start- / Endseite: 1782 - 1798 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440

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