Help Privacy Policy Disclaimer
  Advanced SearchBrowse


  Feasibility and utility of amygdala neurofeedback

Goldway, N., Jalon, I., Keynan, J. N., Hellrung, L., Horstmann, A., Paret, C., et al. (2022). Feasibility and utility of amygdala neurofeedback. Neuroscience and Biobehavioral Reviews, 238: 104694. doi:10.1016/j.neubiorev.2022.104694.

Item is


show Files




Goldway, Noam1, 2, 3, Author
Jalon, Itamar1, 4, Author
Keynan, Jackob N1, 5, 6, Author
Hellrung, Lydia7, 8, Author           
Horstmann, Annette7, 9, 10, Author           
Paret, Christian11, Author
Hendler, Talma1, 2, 3, 4, 12, Author
1Sagol Brain Institute, Tel-Aviv Sourasky Medical Center, Israel, ou_persistent22              
2Sagol School of Neuroscience, Tel-Aviv University, Israel, ou_persistent22              
3Department of Psychology, New York University, NY, USA, ou_persistent22              
4School of Psychological Sciences, Tel-Aviv University, Israel, ou_persistent22              
5Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA, USA, ou_persistent22              
6Wu Tsai Neurosciences Institute, Stanford University, CA, USA, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
8Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Switzerland, ou_persistent22              
9Department of Medicine, University Hospital Leipzig, Germany, ou_persistent22              
10Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
11Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
12Sackler Faculty of Medicine, Tel-Aviv University, Israel, ou_persistent22              


Free keywords: Amygdala; Meta-Analysis; Neurofeedback; PTSD; RDoC; Real-time fMRI
 Abstract: Amygdala dysregulation is a core dysfunction in multiple psychiatric disorders. Thus, the introduction of Amygdala self-modulation through NeuroFeedback (NF) is a valuable non-invasive intervention tool. Yet, the feasibility and best practices of Amygdala-NF have not been systematically examined. The current perspective presents a thorough review of relevant studies, an analytic summary of design parameters, and examination of brain mechanisms related to successful Amygdala-self-modulation. A meta-analysis of 33 publications showed that real Amygdala-NF facilitates learned modulation compared to control conditions. In addition, while variability in design choices could be explained by the involved amygdala-related valance domains (positive, negative), in most cases the targeted neuro-behavioral processes were not directly assessed as an outcome measure. Lastly, re-analyzing six data sets of Amygdala-fMRI-NF revealed that successful Amygdala down-modulation is coupled with deactivation of the posterior insula and nodes in the Default-Mode-Network. Our findings point to Amygdala self-modulation can be acquired using NF. Yet, further controlled studies, relevant tasks before and after treatment, and neural 'target engagement' measures are critically needed to establish efficacy and specificity.


Language(s): eng - English
 Dates: 2022-04-122022-01-292022-05-112022-05-242022-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neubiorev.2022.104694
Other: epub 2022
PMID: 35623447
 Degree: -



Legal Case


Project information

show hide
Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 2923/20
Funding program : -
Funding organization : Israel science foundation
Project name : -
Grant ID : 67951
Funding program : -
Funding organization : Ionnovation authority Israel ministry of commerce
Project name : -
Grant ID : -
Funding program : -
Funding organization : ‘Sagol network’ foundation

Source 1

Title: Neuroscience and Biobehavioral Reviews
Source Genre: Journal
Publ. Info: New York [etc.] : Pergamon
Pages: - Volume / Issue: 238 Sequence Number: 104694 Start / End Page: - Identifier: ISSN: 0149-7634
CoNE: https://pure.mpg.de/cone/journals/resource/954928536106