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  Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes

Streit, A., Wang, J., Kang, Y., & Davis, R. (2016). Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes. Current Opinion in Microbiology, 32, 120-127. doi:10.1016/j.mib.2016.05.012.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-8785-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-777E-0
Genre: Journal Article

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Streit, A1, 2, Author           
Wang, J, Author
Kang, Y, Author
Davis, RE, Author
Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375786              
2Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3507711              

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 Abstract: Maintenance of genome integrity is essential. However, programmed DNA elimination removes specific DNA sequences from the genome during development. DNA elimination occurs in unicellular ciliates and diverse metazoa ranging from nematodes to vertebrates. Two distinct groups of nematodes use DNA elimination to silence germline-expressed genes in the soma (ascarids) or for sex determination (Strongyloides spp.). Data suggest that DNA elimination likely evolved independently in these nematodes. Recent studies indicate that differential CENP-A deposition within chromosomes defines which sequences are retained and lost during Ascaris DNA elimination. Additional studies are needed to determine the distribution, functions, and mechanisms of DNA elimination in nematodes.

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 Dates: 2016-08
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.mib.2016.05.012
PMID: 27315434
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Title: Current Opinion in Microbiology
Source Genre: Journal
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Publ. Info: London : Elsevier Current Trends
Pages: - Volume / Issue: 32 Sequence Number: - Start / End Page: 120 - 127 Identifier: ISSN: 1369-5274
CoNE: https://pure.mpg.de/cone/journals/resource/954925620175