English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Population genetics and signatures of selection in Early Neolithic european farmers

Childebayeva, A., Rohrlach, A. B., Barquera Lozano, R. J., Rivollat, M., Aron, F., Szolek, A., et al. (2022). Population genetics and signatures of selection in Early Neolithic european farmers. Molecular Biology and Evolution, msac108. doi:10.1093/molbev/msac108.

Item is

Files

show Files
hide Files
:
shh3224pre.pdf (Preprint), 2MB
Name:
shh3224pre.pdf
Description:
accepted manuscript. - OA
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show
hide
Description:
CCO 1.0. - (last seen: June 2022)

Creators

show
hide
 Creators:
Childebayeva, Ainash1, Author              
Rohrlach, Adam Ben1, Author              
Barquera Lozano, Rodrigo José1, Author              
Rivollat, Maïté1, Author              
Aron, Franziska1, Author              
Szolek, András, Author
Kohlbacher, Oliver, Author
Nicklisch, Nicole, Author
Alt, Kurt W., Author
Gronenborn, Detlef, Author
Meller, Harald, Author
Friederich, Susanne, Author
Prüfer, Kay1, Author              
Deguilloux, Marie-France, Author
Krause, Johannes1, Author              
Haak, Wolfgang1, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

Content

show
hide
Free keywords: Selection, Neolithization, Ancient DNA, Linear Pottery Culture
 Abstract: Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA (aDNA) research in the last ten years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here we present high quality genome-wide data from the Linear Pottery Culture (LBK) site Derenburg Meerenstieg II (DER) (N=32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the LBK cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called AIMLESS (Admixture-informed Maximum-likelihood Estimation for Selection Scans) that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia.

Details

show
hide
Language(s): eng - English
 Dates: 2022-05-17
 Publication Status: Published online
 Pages: 35
 Publishing info: -
 Table of Contents: Introduction
New Approaches
Results and discussion
- Data generation and authentication.
- Genome-wide data analysis.
- Uniparentally inherited markers.
- Biological Relatedness.
- LBK inter-site comparisons.
- Phenotypic analysis.
- HLA class-I and II allele analysis.
Conclusions
Material and methods
- Archaeological background/site description.
- Sample preparation.
- Genotyping.
- Biological relatedness and Runs of Homozygosity analyses.
- Mitochondrial and Y haplotype analysis.
- Shotgun data.
- HLA typing.
- Selection scans.
- AIMLESS Admixture-Informed Maximum-Likelihood Estimation for Selection Scans.
- Haplotype-based scan.
 Rev. Type: No review
 Identifiers: DOI: 10.1093/molbev/msac108
Other: shh3224
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : PALEoRIDER
Grant ID : 771234
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

Source 1

show
hide
Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: msac108 Start / End Page: - Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119