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  Responsivity of the striatal dopamine system to methylphenidate: A within-subject I-123-β-CIT-SPECT study in male children and adolescents with attention-deficit/hyperactivity disorder

Aster, H.-C., Romanos, M., Walitza, S., Gerlach, M., Mühlberger, A., Rizzo, A., et al. (2022). Responsivity of the striatal dopamine system to methylphenidate: A within-subject I-123-β-CIT-SPECT study in male children and adolescents with attention-deficit/hyperactivity disorder. Frontiers in Psychiatry, 13: 804730. doi:10.3389/fpsyt.2022.804730.

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Aster, Hans-Christoph1, 2, Autor
Romanos, Marcel1, Autor
Walitza, Susanne3, Autor
Gerlach, Manfred1, Autor
Mühlberger, Andreas4, Autor
Rizzo, Albert5, Autor
Andreatta, Marta6, Autor
Hasenauer, Natalie7, Autor
Hartrampf, Philipp E.7, Autor
Nerlich, Kai7, Autor
Reiners, Christoph7, Autor
Lorenz, Reinhard7, Autor
Buck, Andreas K.7, Autor
Deserno, Lorenz1, 8, 9, Autor           
Affiliations:
1Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Würzburg, Germany, ou_persistent22              
2Department of Neurology, University Hospital Würzburg, Germany, ou_persistent22              
3Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Zurich, Switzerland, ou_persistent22              
4Department of Psychology, Clinical Psychology and Psychotherapy, University of Regensburg, Germany, ou_persistent22              
5Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, ou_persistent22              
6Department of Clinical Psychology, Erasmus School of Social and Behavioural Sciences, Rotterdam, Erasmus University Rotterdam, the Netherlands, ou_persistent22              
7Department of Nuclear Medicine, University Hospital Würzburg, Germany, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
9Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              

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Schlagwörter: Methylphenidate; Attention deficit/hyperactivity disorder (ADHD); Striatum; Single photon emission computed tomography (SPECT); Responsivity; Caudate nucleus; Dopamine transporter (DAT)
 Zusammenfassung: Background: Methylphenidate (MPH) is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). MPH binds to the dopamine (DA) transporter (DAT), which has high density in the striatum. Assessments of the striatal dopamine transporter by single positron emission computed tomography (SPECT) in childhood and adolescent patients are rare but can provide insight on how the effects of MPH affect DAT availability. The aim of our within-subject study was to investigate the effect of MPH on DAT availability and how responsivity to MPH in DAT availability is linked to clinical symptoms and cognitive functioning.







Methods: Thirteen adolescent male patients (9–16 years) with a diagnosis of ADHD according to the DSM-IV and long-term stimulant medication (for at least 6 months) with MPH were assessed twice within 7 days using SPECT after application of I-123-β-CIT to examine DAT binding potential (DAT BP). SPECT measures took place in an on- and off-MPH status balanced for order across participants. A virtual reality continuous performance test was performed at each time point. Further clinical symptoms were assessed for baseline off-MPH.







Results: On-MPH status was associated with a highly significant change (−29.9%) of striatal DAT BP as compared to off-MPH (t = −4.12, p = 0.002). A more pronounced change in striatal DAT BP was associated with higher off-MPH attentional and externalizing symptom ratings (Pearson r = 0.68, p = 0.01). Striatal DAT BP off-MPH, but not on-MPH, was associated with higher symptom ratings (Pearson r = 0.56, p = 0.04).







Conclusion: Our findings corroborate previous reports from mainly adult samples that MPH changes striatal DAT BP availability and suggest higher off-MPH DAT BP, likely reflecting low baseline DA levels, as a marker of symptom severity.

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Sprache(n): eng - English
 Datum: 2021-10-292022-02-152022-04-14
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3389/fpsyt.2022.804730
Anderer: eCollection 2022
PMID: 35492708
PMC: PMC9046584
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Projektname : -
Grant ID : 01EO150
Förderprogramm : -
Förderorganisation : Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : -
Förderprogramm : (5397423; 402170461)
Förderorganisation : German Research Foundation (DFG)

Quelle 1

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Titel: Frontiers in Psychiatry
  Kurztitel : Front Psychiatry
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Lausanne, Switzerland : Frontiers Research Foundation
Seiten: - Band / Heft: 13 Artikelnummer: 804730 Start- / Endseite: - Identifikator: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640