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  A convergent structure-function substrate of cognitive imbalances in autism

Hong, S.-J., Mottron, L., Park, B.-y., Benkarim, O., Valk, S. L., Paquola, C., et al. (2023). A convergent structure-function substrate of cognitive imbalances in autism. Cerebral Cortex, 33(5), 1566-1580. doi:10.1093/cercor/bhac156.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-8E5F-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-117F-2
Genre: Journal Article

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Locator:
https://www.biorxiv.org/content/10.1101/2021.01.14.426284v1 (Preprint)
Description:
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OA-Status:
Green

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 Creators:
Hong, Seok-Jun1, 2, 3, 4, Author
Mottron, Laurent5, Author
Park, Bo-yong1, 2, 6, Author
Benkarim, Oualid1, Author
Valk, Sofie L.1, 7, 8, 9, Author           
Paquola, Casey1, 8, Author
Larivière, Sara1, Author
Vos de Wael, Reinder1, Author
Degré-Pelletier, Janie1, 10, Author
Soulieres, Isabelle10, Author
Ramphal, Bruce11, Author
Margolis, Amy11, Author
Milham, Michael4, 12, Author
Di Martino, Adriana13, Author
Bernhardt, Boris C.1, Author
Affiliations:
1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
2Center for Neuroscience Imaging Research, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
3Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
4Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
5Department of Psychiatry, University of Montréal, QC, Canada, ou_persistent22              
6Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22              
7Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
8Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
9Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
10Department of Psychology, University of Montréal, QC, Canada, ou_persistent22              
11New York State Psychiatric Institute, Columbia University Medical Center, NY, USA, ou_persistent22              
12Center for Biomedical Imaging and Neuromodulation (C-BIN), Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
13Autism Center, Child Mind Institute, New York, NY, USA, ou_persistent22              

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Free keywords: Autism; Cognitive imbalance; Multimodal neuroimaging; Neurosubtyping; Verbal and nonverbal IQ
 Abstract:
Background: Autism spectrum disorder (ASD) is a common neurodevelopmental diagnosis showing substantial phenotypic heterogeneity. A leading example can be found in verbal and nonverbal cognitive skills, which vary from elevated to impaired compared with neurotypical individuals. Moreover, deficits in verbal profiles often coexist with normal or superior performance in the nonverbal domain.

Methods: To study brain substrates underlying cognitive imbalance in ASD, we capitalized categorical and dimensional IQ profiling as well as multimodal neuroimaging.

Results: IQ analyses revealed a marked verbal to nonverbal IQ imbalance in ASD across 2 datasets (Dataset-1: 155 ASD, 151 controls; Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in Dataset-1 revealed a structure-function substrate of cognitive imbalance, characterized by atypical cortical thickening and altered functional integration of language networks alongside sensory and higher cognitive areas.

Conclusion: Although verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.

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Language(s): eng - English
 Dates: 2022-03-282021-12-102022-03-292022-05-122023-02-20
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhac156
PMID: 35552620
 Degree: -

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Project information

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Project name : -
Grant ID : 28436
Funding program : -
Funding organization : Brain & Behavior Research Foundation
Project name : -
Grant ID : IBS-R015-D1
Funding program : -
Funding organization : Institute for Basic Science
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Grant ID : -
Funding program : -
Funding organization : Fonds de la Recherche du Québec—Santé (FRQ-S)
Project name : -
Grant ID : FDN-154298
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Richard and Ann Sievers Award
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Grant ID : -
Funding program : -
Funding organization : Molson Engineering
Project name : -
Grant ID : NRF-2020R1A6A3A03037088; NRF-2021R1F1A1052303
Funding program : -
Funding organization : National Research Foundation of Korea (NRF)
Project name : Institute for Information and Communications Technology Planning and Evaluation (IITP)
Grant ID : 2020-0-01389; 2021-0-02068
Funding program : -
Funding organization : Korea Government (MSIT)
Project name : -
Grant ID : R21MH107045-01; R01MH105506; R01MH115363
Funding program : -
Funding organization : National Institute of Mental Health (NIMH)
Project name : -
Grant ID : R01 ES030950; R01 ES027424; K23ES026239
Funding program : -
Funding organization : National Institute of Environmental Health Sciences (NIEHS)
Project name : -
Grant ID : 1UG3OD023290
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation
Project name : -
Grant ID : Discovery-1304413
Funding program : -
Funding organization : National Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Azrieli Center for Autism Research (ACAR)
Project name : -
Grant ID : -
Funding program : -
Funding organization : BrainCanada (Azrieli Future Leaders)

Source 1

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 33 (5) Sequence Number: - Start / End Page: 1566 - 1580 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440