A convergent structure-function substrate of cognitive imbalances in autism

Hong, Seok-Jun; Mottron, Laurent; Park, Bo-yong; Benkarim, Oualid; Valk, Sofie L.; Paquola, Casey; Larivière, Sara; Vos de Wael, Reinder; Degré-Pelletier, Janie; Soulieres, Isabelle; Ramphal, Bruce; Margolis, Amy; Milham, Michael; Di Martino, Adriana; Bernhardt, Boris C.

doi:10.1093/cercor/bhac156

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A convergent structure-function substrate of cognitive imbalances in autism

Hong, S.-J., Mottron, L., Park, B.-y., Benkarim, O., Valk, S. L., Paquola, C., et al. (2023). A convergent structure-function substrate of cognitive imbalances in autism. Cerebral Cortex, 33(5), 1566-1580. doi:10.1093/cercor/bhac156.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-8E5F-D Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-117F-2

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https://www.biorxiv.org/content/10.1101/2021.01.14.426284v1 (Preprint) Open Access Grün

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Hong, Seok-Jun^{1, 2, 3, 4}, Autor
Mottron, Laurent⁵, Autor
Park, Bo-yong^{1, 2, 6}, Autor
Benkarim, Oualid¹, Autor
Valk, Sofie L.^{1, 7, 8, 9}, Autor
Paquola, Casey^{1, 8}, Autor
Larivière, Sara¹, Autor
Vos de Wael, Reinder¹, Autor
Degré-Pelletier, Janie^{1, 10}, Autor
Soulieres, Isabelle¹⁰, Autor
Ramphal, Bruce¹¹, Autor
Margolis, Amy¹¹, Autor
Milham, Michael^{4, 12}, Autor
Di Martino, Adriana¹³, Autor
Bernhardt, Boris C.¹, Autor

Affiliations:
1Multimodal Imaging and Connectome Analysis Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22
2Center for Neuroscience Imaging Research, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22
3Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22
4Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22
5Department of Psychiatry, University of Montréal, QC, Canada, ou_persistent22
6Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22
7Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264
8Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22
9Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22
10Department of Psychology, University of Montréal, QC, Canada, ou_persistent22
11New York State Psychiatric Institute, Columbia University Medical Center, NY, USA, ou_persistent22
12Center for Biomedical Imaging and Neuromodulation (C-BIN), Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22
13Autism Center, Child Mind Institute, New York, NY, USA, ou_persistent22

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Schlagwörter: Autism; Cognitive imbalance; Multimodal neuroimaging; Neurosubtyping; Verbal and nonverbal IQ

Zusammenfassung:
Background: Autism spectrum disorder (ASD) is a common neurodevelopmental diagnosis showing substantial phenotypic heterogeneity. A leading example can be found in verbal and nonverbal cognitive skills, which vary from elevated to impaired compared with neurotypical individuals. Moreover, deficits in verbal profiles often coexist with normal or superior performance in the nonverbal domain.

Methods: To study brain substrates underlying cognitive imbalance in ASD, we capitalized categorical and dimensional IQ profiling as well as multimodal neuroimaging.

Results: IQ analyses revealed a marked verbal to nonverbal IQ imbalance in ASD across 2 datasets (Dataset-1: 155 ASD, 151 controls; Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in Dataset-1 revealed a structure-function substrate of cognitive imbalance, characterized by atypical cortical thickening and altered functional integration of language networks alongside sensory and higher cognitive areas.

Conclusion: Although verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.

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Sprache(n): eng - English

Datum: Geändert: 2022-03-28Eingereicht: 2021-12-10Angenommen: 2022-03-29Online veröffentlicht: 2022-05-12Erschienen: 2023-02-20

Publikationsstatus: Erschienen

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Identifikatoren: DOI: 10.1093/cercor/bhac156
PMID: 35552620

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Grant ID : 28436

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Förderorganisation : Brain & Behavior Research Foundation

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Grant ID : IBS-R015-D1

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Förderorganisation : Institute for Basic Science

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Förderorganisation : Fonds de la Recherche du Québec—Santé (FRQ-S)

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Grant ID : FDN-154298

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Förderorganisation : Canadian Institutes of Health Research (CIHR)

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Förderorganisation : Richard and Ann Sievers Award

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Förderorganisation : Molson Engineering

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Grant ID : NRF-2020R1A6A3A03037088; NRF-2021R1F1A1052303

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Förderorganisation : National Research Foundation of Korea (NRF)

Projektname : Institute for Information and Communications Technology Planning and Evaluation (IITP)

Grant ID : 2020-0-01389; 2021-0-02068

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Förderorganisation : Korea Government (MSIT)

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Grant ID : R21MH107045-01; R01MH105506; R01MH115363

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Förderorganisation : National Institute of Mental Health (NIMH)

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Grant ID : R01 ES030950; R01 ES027424; K23ES026239

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Förderorganisation : National Institute of Environmental Health Sciences (NIEHS)

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Grant ID : 1UG3OD023290

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Förderorganisation : National Institutes of Health (NIH)

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Grant ID : NI17-039

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Förderorganisation : SickKids Foundation

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Grant ID : Discovery-1304413

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Förderorganisation : National Sciences and Engineering Research Council of Canada (NSERC)

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Förderorganisation : Azrieli Center for Autism Research (ACAR)

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Förderorganisation : BrainCanada (Azrieli Future Leaders)

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Titel: Cerebral Cortex

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: New York, NY : Oxford University Press

Seiten: - Band / Heft: 33 (5) Artikelnummer: - Start- / Endseite: 1566 - 1580 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440

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