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  Control of leaf morphogenesis by microRNAs

Palatnik, J., Allen, E., Wu, X., Schommer, C., Schwab, R., Carrington, J., et al. (2003). Control of leaf morphogenesis by microRNAs. Nature, 425(6955), 257-263. doi:10.1038/nature01958.

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 Creators:
Palatnik, JF1, Author           
Allen, E, Author
Wu, X, Author
Schommer, C1, Author           
Schwab, R1, Author           
Carrington, JC, Author
Weigel, D1, Author           
Affiliations:
1Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375790              

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 Abstract: Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.

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 Dates: 2003-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/nature01958
PMID: 12931144
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 425 (6955) Sequence Number: - Start / End Page: 257 - 263 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238