English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  First clinical application of a novel T1 mapping of the whole brain

Müller, S. J., Khadhraoui, E., Voit, D., Riedel, C. H., Frahm, J., & Ernst, M. S. (2022). First clinical application of a novel T1 mapping of the whole brain. The Neuroradiology Journal, in press. doi:10.1177/19714009221084244.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
3386920.pdf (Preprint), 2MB
Name:
3386920.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Müller, S. J., Author
Khadhraoui, E., Author
Voit, D.1, Author
Riedel, C. H., Author
Frahm, J.1, Author              
Ernst, M. S., Author
Affiliations:
1Research Group Biomedical NMR, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350294              

Content

show
hide
Free keywords: T1 mapping, quantitative magnetic resonance imaging, T1 relaxation time
 Abstract: Background: The aim of this study was to evaluate the reproducibility and clinical value of the novel single-shot T1 mapping method for rapid and accurate multi-slice coverage of the whole brain, described by Wang et al. 2015. Methods: At a field strength of 3 Tesla, T1 mappings of 139 patients (51 of them without pathologic findings) and two repeats of five volunteers were performed at 0.5 mm in-plane resolution. Mean T1 values were determined in 18 manually segmented regions-of-interest without pathologic findings. Reproducibility of the repeated scans was calculated using mean coefficient of variations. Pathologies were grouped and separately evaluated. Results: The mean age of the cohort was 49 (range 1-95 years). T1 relaxation times for ordinary brain and pathologies were in accordance with the literature values. Intra- and inter-subject reproducibility was excellent, and mean coefficient of variations were 2.4% and 3.8%, respectively. Discussion: The novel rapid T1 mapping method is a reliable magnetic resonance imaging technique for identifying and quantifying normal brain structures and may thus serve as a basis for assessing pathologies. The fast and parallel online calculation enables a comfortable use in everyday clinical practice. We see a possible clinical value in a large spectrum of diseases, which should be investigated in further studies.

Details

show
hide
Language(s): eng - English
 Dates: 2022-04-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1177/19714009221084244
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Neuroradiology Journal
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: in press Start / End Page: - Identifier: -