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  First clinical application of a novel T1 mapping of the whole brain

Müller, S. J., Khadhraoui, E., Voit, D., Riedel, C. H., Frahm, J., & Ernst, M. S. (2022). First clinical application of a novel T1 mapping of the whole brain. The Neuroradiology Journal, 35(6), 684-691. doi:10.1177/19714009221084244.

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Müller, S. J., Author
Khadhraoui, E., Author
Voit, D.1, Author           
Riedel, C. H., Author
Frahm, J.1, Author           
Ernst, M. S., Author
Affiliations:
1Research Group Biomedical NMR, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350294              

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Free keywords: T1 mapping, quantitative magnetic resonance imaging, T1 relaxation time
 Abstract: Background: The aim of this study was to evaluate the reproducibility and clinical value of the novel single-shot T1 mapping method for rapid and accurate multi-slice coverage of the whole brain, described by Wang et al. 2015.

Methods: At a field strength of 3 Tesla, T1 mappings of 139 patients (51 of them without pathologic findings) and two repeats of five volunteers were performed at 0.5 mm in-plane resolution. Mean T1 values were determined in 18 manually segmented regions-of-interest without pathologic findings. Reproducibility of the repeated scans was calculated using mean coefficient of variations. Pathologies were grouped and separately evaluated.

Results: The mean age of the cohort was 49 (range 1-95 years). T1 relaxation times for ordinary brain and pathologies were in accordance with the literature values. Intra- and inter-subject reproducibility was excellent, and mean coefficient of variations were 2.4% and 3.8%, respectively.

Discussion: The novel rapid T1 mapping method is a reliable magnetic resonance imaging technique for identifying and quantifying normal brain structures and may thus serve as a basis for assessing pathologies. The fast and parallel online calculation enables a comfortable use in everyday clinical practice. We see a possible clinical value in a large spectrum of diseases, which should be investigated in further studies.

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Language(s): eng - English
 Dates: 2022-04-212022
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1177/19714009221084244
 Degree: -

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Title: The Neuroradiology Journal
  Other : NRJ
Source Genre: Journal
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Publ. Info: SAGE Publishing
Pages: - Volume / Issue: 35 (6) Sequence Number: - Start / End Page: 684 - 691 Identifier: Other: ISSN
CoNE: https://pure.mpg.de/cone/journals/resource/2385-1996