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  Functionalization of cellular membranes with DNA nanotechnology

Schoenit, A., Cavalcanti-Adam, E. A., & Göpfrich, K. (2021). Functionalization of cellular membranes with DNA nanotechnology. Trends in Biotechnology, 39(11), 1208-1220. doi:10.1016/j.tibtech.2021.02.002.

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TrendsBiotechnol_39_2021_1208.pdf (Any fulltext), 3MB
 
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Schoenit, Andreas1, Author           
Cavalcanti-Adam, Elisabetta Ada1, Author           
Göpfrich, Kerstin1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: cellular plasma membrane, DNA nanotechnology, cell biology, DNA origami, membrane engineering, lipid bilayer
 Abstract: Due to its versatility and programmability, DNA nanotechnology has greatly expanded the experimental toolbox for biomedical research. Recent advances allow reliable and efficient functionalization of cellular plasma membranes with a variety of synthetic DNA constructs, ranging from single strands to complex 3D DNA origami. The scope for applications, which probe biophysical parameters or equip cells with novel functions, is rapidly increasing. These applications extend from programmed cellular connectivity and tissue engineering to molecular force measurements, controlled receptor–ligand interactions, membrane-anchored biosensors, and artificial transmembrane structures. Here, we give guidance on different strategies to functionalize cellular membranes with DNA nanotechnology and summarize current trends employing membrane-anchored DNA as a tool in biophysics, cell biology, and synthetic biology.

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Language(s): eng - English
 Dates: 2021-11
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tibtech.2021.02.002
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Title: Trends in Biotechnology
  Other : Trends Biotechnol.
Source Genre: Journal
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Publ. Info: Amsterdam, Netherlands : Elsevier Current Trends
Pages: - Volume / Issue: 39 (11) Sequence Number: - Start / End Page: 1208 - 1220 Identifier: ISSN: 0167-7799
CoNE: https://pure.mpg.de/cone/journals/resource/110984180788411