The genomic basis of parasitism in the Strongyloides clade of nematodes

Hunt, VL; Tsai, IJ; Coghlan, A; Reid, AJ; Holroyd, N; Foth, BJ; Tracey, A; Cotton, JA; Stanley, EJ; Beasley, H; Bennett, HM; Brooks, K; Harsha, B; Kajitani, R; Kulkarni, A; Harbecke, D; Nagayasu, E; Nichol, S; Ogura, Y; Quail, MA; Randle, N; Xia, D; Brattig, NW; Soblik, H; Ribeiro, DM; Sanchez-Flores, A; Hayashi, T; Itoh, T; Denver, DR; Grant, W; Stoltzfus, JD; Lok, JB; Murayama, H; Wastling, J; Streit, A; Kikuchi, T; Viney, M; Berriman, M

doi:10.1038/ng.3495

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The genomic basis of parasitism in the Strongyloides clade of nematodes

Hunt, V., Tsai, I., Coghlan, A., Reid, A., Holroyd, N., Foth, B., et al. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. doi:10.1038/ng.3495.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-930D-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-77F5-8

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Hunt, VL, Author
Tsai, IJ, Author
Coghlan, A, Author
Reid, AJ, Author
Holroyd, N, Author
Foth, BJ, Author
Tracey, A, Author
Cotton, JA, Author
Stanley, EJ, Author
Beasley, H, Author
Bennett, HM, Author
Brooks, K, Author
Harsha, B, Author
Kajitani, R, Author
Kulkarni, A^{1, 2}, Author
Harbecke, D^{1, 2}, Author
Nagayasu, E, Author
Nichol, S, Author
Ogura, Y, Author
Quail, MA, Author
Randle, N, AuthorXia, D, AuthorBrattig, NW, AuthorSoblik, H, AuthorRibeiro, DM, AuthorSanchez-Flores, A, AuthorHayashi, T, AuthorItoh, T, AuthorDenver, DR, AuthorGrant, W, AuthorStoltzfus, JD, AuthorLok, JB, AuthorMurayama, H, AuthorWastling, J, AuthorStreit, A^{1, 2}, Author         Kikuchi, T, AuthorViney, M, AuthorBerriman, M, Author more..

Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375786
2Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3507711

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Abstract: Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

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Dates: Date issued: 2016-03

Publication Status: Issued

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Identifiers: DOI: 10.1038/ng.3495
PMID: 26829753

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Title: Nature Genetics

Other : Nature Genet.

Source Genre: Journal

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Publ. Info: New York, NY : Nature America, Inc.

Pages: - Volume / Issue: 48 (3) Sequence Number: - Start / End Page: 299 - 307 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609