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  Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

Hassouna, I., Ott, C., Wüstefeld, L., Offen, N., Neher, R., Mitkovski, M., Winkler, D., Sperling, S., Fries, L., Goebbels, S., Vreja, I., Hagemeyer, N., Dittrich, M., Rossetti, M., Kröhnert, K., Hannke, K., Boretius, S., Zeug, A., Höschen, C., Dandekar, T., Dere, E., Neher, E., Rizzoli, S., Nave, K., Sirén, A., & Ehrenreich, H. (2016). Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus. Molecular Psychiatry, 21(12), 1752-1767. doi:10.1038/mp.2015.212.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000A-9448-E 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000A-9449-D
資料種別: 学術論文

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 作成者:
Hassouna, I, 著者
Ott, C, 著者
Wüstefeld, L, 著者
Offen, N, 著者
Neher, RA1, 著者           
Mitkovski, M, 著者
Winkler, D, 著者
Sperling, S, 著者
Fries, L, 著者
Goebbels, S, 著者
Vreja, IC, 著者
Hagemeyer, N, 著者
Dittrich, M, 著者
Rossetti, MF, 著者
Kröhnert, K, 著者
Hannke, K, 著者
Boretius, S, 著者
Zeug, A, 著者
Höschen, C, 著者
Dandekar, T, 著者
Dere, E, 著者Neher, E, 著者Rizzoli, SO, 著者Nave, KA, 著者Sirén, AL, 著者Ehrenreich, H, 著者 全て表示
所属:
1Research Group Evolutionary Dynamics and Biophysics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3377926              

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 要旨: Recombinant human erythropoietin (EPO) improves cognitive performance in neuropsychiatric diseases ranging from schizophrenia and multiple sclerosis to major depression and bipolar disease. This consistent EPO effect on cognition is independent of its role in hematopoiesis. The cellular mechanisms of action in brain, however, have remained unclear. Here we studied healthy young mice and observed that 3-week EPO administration was associated with an increased number of pyramidal neurons and oligodendrocytes in the hippocampus of ~20%. Under constant cognitive challenge, neuron numbers remained elevated until >6 months of age. Surprisingly, this increase occurred in absence of altered cell proliferation or apoptosis. After feeding a 15N-leucine diet, we used nanoscopic secondary ion mass spectrometry, and found that in EPO-treated mice, an equivalent number of neurons was defined by elevated 15N-leucine incorporation. In EPO-treated NG2-Cre-ERT2 mice, we confirmed enhanced differentiation of preexisting oligodendrocyte precursors in the absence of elevated DNA synthesis. A corresponding analysis of the neuronal lineage awaits the identification of suitable neuronal markers. In cultured neurospheres, EPO reduced Sox9 and stimulated miR124, associated with advanced neuronal differentiation. We are discussing a resulting working model in which EPO drives the differentiation of non-dividing precursors in both (NG2+) oligodendroglial and neuronal lineages. As endogenous EPO expression is induced by brain injury, such a mechanism of adult neurogenesis may be relevant for central nervous system regeneration.

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言語: eng - English
 日付: 2016-012016-12
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1038/mp.2015.212
PMID: 26809838
 学位: -

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出版物 1

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出版物名: Molecular Psychiatry
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Houndmills, Hampshire, UK : Stockton Press
ページ: - 巻号: 21 (12) 通巻号: - 開始・終了ページ: 1752 - 1767 識別子(ISBN, ISSN, DOIなど): ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131