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  Cohort profile: The LIFE-adult-study

Engel, C., Wirkner, K., Zeynalova, S., Baber, R., Binder, H., Ceglarek, U., et al. (2022). Cohort profile: The LIFE-adult-study. International Journal of Epidemiology. doi:10.1093/ije/dyac114.

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Engel, Christoph1, 2, Author
Wirkner, Kerstin1, 2, Author
Zeynalova, Samira1, 2, Author
Baber, Ronny2, 3, Author
Binder, Hans4, Author
Ceglarek, Uta2, 3, Author
Enzenbach, Cornelia1, 2, Author
Fuchs, Michael2, 5, Author
Hagendorff, Andreas6, Author
Henger, Sylvia1, 2, Author
Hinz, Andreas7, Author
Rauscher, Franziska G1, 2, Author
Reusche, Matthias1, 2, Author
Riedel-Heller, Steffi G8, Author
Röhr, Susanne8, 9, Author
Sacher, Julia10, 11, Author           
Sander, Christian2, 12, Author
Schroeter, Matthias L.10, 11, Author           
Tarnok, Attila1, 13, Author
Treudler, Regina14, 15, Author
Villringer, Arno10, 11, Author           Wachter, Rolf16, AuthorWitte, A. Veronica10, 11, Author           Thiery, Joachim2, 3, AuthorScholz, Markus1, 2, AuthorLoeffler, Markus1, 2, AuthorLIFE-Adult-Study working group, Author               more..
1Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
4Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Germany, ou_persistent22              
5Section of Phoniatrics and Audiology, Department of Otorhinolaryngology, University of Leipzig, Germany, ou_persistent22              
6Department of Cardiology, University of Leipzig, Germany, ou_persistent22              
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
8Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Germany, ou_persistent22              
9Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
11Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
12Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
13Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
14Department of Dermatology, Venereology and Allergology, University of Leipzig, Germany, ou_persistent22              
15Leipzig Interdisciplinary Allergy Center (LICA), University Hospital Leipzig, Germany, ou_persistent22              
16Clinic and Policlinic for Cardiology, University Hospital Leipzig, Germany, ou_persistent22              


Free keywords: Adult; Follow-up; Germany
 Abstract: The LIFE-Adult-Study is a population-based cohort study investigating the prevalence and incidence of common diseases and subclinical disease phenotypes, the complex interactions between genetic and lifestyle factors regarding the co-occurrence and development of subclinical phenotypes and diseases, and the role of biomarkers to predict disease initiation and progression. The study comprises an age-stratified and sex-stratified random sample of 10 000 adult individuals (aged 18–79 years) from Leipzig, Germany. The baseline assessment was conducted from August 2011 to November 2014 and the first follow-up was conducted from October 2017 to August 2021. A total of 5512 individuals completed postal follow-up questionnaires and 1799 individuals participated in a physical examination follow-up programme. The study focuses on cardiovascular and metabolic disorders, cognition and brain function, depression, sleep disorders and electroencephalography-vigilance regulation, eye diseases, voice and allergies. The assessment programme comprises physical and medical examinations, personal interviews, self-administered questionnaires, psychometric tests, and clinical chemistry from blood and urine samples (including biobank asservation).


Language(s): eng - English
 Dates: 2021-09-212022-05-102022-05-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/ije/dyac114
Other: online ahead of print
PMID: 35640047
 Degree: -



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Project information

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Project name : -
Grant ID : 031L0026
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : R21 EY030142-01, R21 EY030631-01, R01 EY030575-01
Funding program : -
Funding organization : National Institutes of Health
Project name : -
Grant ID : 209933838 A01–SFB 1052
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

Source 1

Title: International Journal of Epidemiology
  Other : Intern. J. Epidemiol.
Source Genre: Journal
Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0300-5771
CoNE: https://pure.mpg.de/cone/journals/resource/954925508344