Cohort profile: The LIFE-adult-study

Engel, Christoph; Wirkner, Kerstin; Zeynalova, Samira; Baber, Ronny; Binder, Hans; Ceglarek, Uta; Enzenbach, Cornelia; Fuchs, Michael; Hagendorff, Andreas; Henger, Sylvia; Hinz, Andreas; Rauscher, Franziska G; Reusche, Matthias; Riedel-Heller, Steffi G; Röhr, Susanne; Sacher, Julia; Sander, Christian; Schroeter, Matthias L.; Tarnok, Attila; Treudler, Regina; Villringer, Arno; Wachter, Rolf; Witte, A. Veronica; Thiery, Joachim; Scholz, Markus; Loeffler, Markus; LIFE-Adult-Study working group

doi:10.1093/ije/dyac114

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Cohort profile: The LIFE-adult-study

Engel, C., Wirkner, K., Zeynalova, S., Baber, R., Binder, H., Ceglarek, U., et al. (2023). Cohort profile: The LIFE-adult-study. International Journal of Epidemiology, 52(1), e66-e79. doi:10.1093/ije/dyac114.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-951C-F Version Permalink: https://hdl.handle.net/21.11116/0000-000D-EF62-8

Genre: Journal Article

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Creators:
Engel, Christoph^{1, 2}, Author
Wirkner, Kerstin^{1, 2}, Author
Zeynalova, Samira^{1, 2}, Author
Baber, Ronny^{2, 3}, Author
Binder, Hans⁴, Author
Ceglarek, Uta^{2, 3}, Author
Enzenbach, Cornelia^{1, 2}, Author
Fuchs, Michael^{2, 5}, Author
Hagendorff, Andreas⁶, Author
Henger, Sylvia^{1, 2}, Author
Hinz, Andreas⁷, Author
Rauscher, Franziska G^{1, 2}, Author
Reusche, Matthias^{1, 2}, Author
Riedel-Heller, Steffi G⁸, Author
Röhr, Susanne^{8, 9}, Author
Sacher, Julia^{10, 11, 12}, Author
Sander, Christian^{2, 13}, Author
Schroeter, Matthias L.^{10, 11}, Author
Tarnok, Attila^{1, 14}, Author
Treudler, Regina^{15, 16}, Author
Villringer, Arno^{10, 11}, Author         Wachter, Rolf¹⁷, AuthorWitte, A. Veronica^{10, 11}, Author         Thiery, Joachim^{2, 3}, AuthorScholz, Markus^{1, 2}, AuthorLoeffler, Markus^{1, 2}, AuthorLIFE-Adult-Study working group, Author             more..

Affiliations:
1Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22
3Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22
4Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Germany, ou_persistent22
5Section of Phoniatrics and Audiology, Department of Otorhinolaryngology, University of Leipzig, Germany, ou_persistent22
6Department of Cardiology, University of Leipzig, Germany, ou_persistent22
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22
8Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Germany, ou_persistent22
9Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland, ou_persistent22
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22
11Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549
12Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775
13Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22
14Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22
15Department of Dermatology, Venereology and Allergology, University of Leipzig, Germany, ou_persistent22
16Leipzig Interdisciplinary Allergy Center (LICA), University Hospital Leipzig, Germany, ou_persistent22
17Clinic and Policlinic for Cardiology, University Hospital Leipzig, Germany, ou_persistent22

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Free keywords: Adult; Follow-up; Germany

Abstract: The LIFE-Adult-Study is a population-based cohort study investigating the prevalence and incidence of common diseases and subclinical disease phenotypes, the complex interactions between genetic and lifestyle factors regarding the co-occurrence and development of subclinical phenotypes and diseases, and the role of biomarkers to predict disease initiation and progression.

The study comprises an age-stratified and sex-stratified random sample of 10 000 adult individuals (aged 18–79 years) from Leipzig, Germany. The baseline assessment was conducted from August 2011 to November 2014 and the first follow-up was conducted from October 2017 to August 2021. A total of 5512 individuals completed postal follow-up questionnaires and 1799 individuals participated in a physical examination follow-up programme.

The study focuses on cardiovascular and metabolic disorders, cognition and brain function, depression, sleep disorders and electroencephalography-vigilance regulation, eye diseases, voice and allergies. The assessment programme comprises physical and medical examinations, personal interviews, self-administered questionnaires, psychometric tests, and clinical chemistry from blood and urine samples (including biobank asservation).

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Language(s): eng - English

Dates: Submitted: 2021-09-21Accepted: 2022-05-10Published Online: 2022-05-28Date issued: 2023-02

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: DOI: 10.1093/ije/dyac114
PMID: 35640047

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Project name : -

Grant ID : 031L0026

Funding program : -

Funding organization : Federal Ministry of Education and Research (BMBF)

Project name : -

Grant ID : R21 EY030142-01; R21 EY030631-01; R01 EY030575-01

Funding program : -

Funding organization : National Institutes of Health (NIH)

Project name : -

Grant ID : 209933838 A01–SFB 1052

Funding program : -

Funding organization : Deutsche Forschungsgemeinschaft (DFG)

Project name : LIFE—Leipzig Research Centre for Civilization Diseases, Medical Faculty of Leipzig

Grant ID : -

Funding program : (713–241202; 713–241202; 14505/2470; 14575/2470)

Funding organization : European Union, the European Regional Development Fund (ERDF) and the Free State of Saxony

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Title: International Journal of Epidemiology

Other : Intern. J. Epidemiol.

Source Genre: Journal

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Publ. Info: Oxford : Oxford University Press

Pages: - Volume / Issue: 52 (1) Sequence Number: - Start / End Page: e66 - e79 Identifier: ISSN: 0300-5771
CoNE: https://pure.mpg.de/cone/journals/resource/954925508344