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  The effect of right temporal lobe gliomas on left and right hemisphere neural processing during speech perception and production tasks

Yamamoto, A. K., Sanjuán, A., Pope, R., Parker Jones, O., Hope, T. M. H., Prejawa, S., et al. (2022). The effect of right temporal lobe gliomas on left and right hemisphere neural processing during speech perception and production tasks. Frontiers in Human Neuroscience, 16: 803163. doi:10.3389/fnhum.2022.803163.

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 Creators:
Yamamoto, Adam Kenji1, 2, Author
Sanjuán, Ana3, 4, Author
Pope, Rebecca4, Author
Parker Jones, Oiwi4, 5, Author
Hope, Thomas M. H.4, Author
Prejawa, Suse4, 6, 7, Author              
Oberhuber, Marion4, Author
Mancini, Laura1, 2, Author
Ekert, Justyna O.4, Author
Garjardo-Vidal, Andrea4, 8, Author
Creasey, Megan4, Author
Yousry, Tarek A.1, 2, Author
Green, David W.9, Author
Price, Cathy J.4, Author
Affiliations:
1Neuroradiological Academic Unit, Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
2Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ou_persistent22              
3Neuropsychology and Functional Imaging Group, Jaume I University, Castellón de la Plana, Spain, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
6Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
8Faculty of Health Sciences, Universidad del Desarrollo, Concepcion, Chile, ou_persistent22              
9Department of Experimental Psychology, Faculty of Brain Sciences, University College London, United Kingdom, ou_persistent22              

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Free keywords: fMRI; Gliomas; Language; Neurosurgery; Right temporal lobe; Speech perception; Speech production
 Abstract: Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical participants and 16 patients with tumours that preserved the right postero-superior temporal lobe, with enhanced activation within the (tumour-free) contralateral left superior temporal lobe. In contrast, when correctly naming objects (a speech production task), the patients with right postero-superior temporal lobe tumours showed higher activation than both control groups in the same right postero-superior temporal lobe region that was under-activated during auditory semantic matching. The task dependent pattern of under-activation during the auditory speech task and over-activation during object naming was also observed in eight stroke patients with right hemisphere infarcts that affected the right postero-superior temporal lobe compared to eight stroke patients with right hemisphere infarcts that spared it. These task-specific and site-specific cross-pathology effects highlight the importance of the right temporal lobe for language processing and motivate further study of how right temporal lobe tumours affect language performance and neural reorganisation. These findings may have important implications for surgical management of these patients, as knowledge of the regions showing functional reorganisation may help to avoid their inadvertent damage during neurosurgery.

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Language(s): eng - English
 Dates: 2021-10-272022-03-282022-05-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnhum.2022.803163
Other: eCollection 2022
PMID: 35652007
PMC: PMC9148966
 Degree: -

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Project name : -
Grant ID : 205103/Z/16/Z; 203147/Z/16/Z
Funding program : -
Funding organization : Wellcome Trust

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 16 Sequence Number: 803163 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161