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  The influence of white matter lesions on the electric field in transcranial electric stimulation

Kalloch, B., Weise, K., Lampe, L., Bazin, P.-L., Villringer, A., Hlawitschka, M., et al. (2022). The influence of white matter lesions on the electric field in transcranial electric stimulation. NeuroImage: Clinical, 35: 103071. doi:10.1016/j.nicl.2022.103071.

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 Creators:
Kalloch, Benjamin1, 2, 3, 4, Author              
Weise, Konstantin3, 5, Author              
Lampe, Leonie1, Author              
Bazin, Pierre-Louis1, 6, Author              
Villringer, Arno1, Author              
Hlawitschka, Mario2, Author
Sehm, Bernhard1, 7, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Faculty of Computer Science and Media, University of Applied Sciences, Germany, ou_persistent22              
3Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
4Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              
5Department of Advanced Electromagnetics, TU Ilmenau, Germany, ou_persistent22              
6Faculty of Social and Behavioural Science, University of Amsterdam, the Netherlands, ou_persistent22              
7Department of Neurology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              

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Free keywords: Transcranial electrical stimulation; Transcranial direct current stimulation; White matter lesions; White matter hyperintensities; Uncertainty analysis; Aging effects
 Abstract: Background Transcranial direct current stimulation (tDCS) is a promising tool to enhance therapeutic efforts, for instance, after a stroke. The achieved stimulation effects exhibit high inter-subject variability, primarily driven by perturbations of the induced electric field (EF). Differences are further elevated in the aging brain due to anatomical changes such as atrophy or lesions. Informing tDCS protocols by computer-based, individualized EF simulations is a suggested measure to mitigate this variability. Objective While brain anatomy in general and specifically atrophy as well as stroke lesions are deemed influential on the EF in simulation studies, the influence of the uncertainty in the change of the electrical properties of the white matter due to white matter lesions (WMLs) has not been quantified yet. Methods A group simulation study with 88 subjects assigned into four groups of increasing lesion load was conducted. Due to the lack of information about the electrical conductivity of WMLs, an uncertainty analysis was employed to quantify the variability in the simulation when choosing an arbitrary conductivity value for the lesioned tissue. Results The contribution of WMLs to the EF variance was on average only one tenth to one thousandth of the contribution of the other modeled tissues. While the contribution of the WMLs significantly increased ( in subjects exhibiting a high lesion load compared to low lesion load subjects, typically by a factor of 10 and above, the total variance of the EF didnot change with the lesion load. Conclusion Our results suggest that WMLs do not perturb the EF globally and can thus be omitted when modeling subjects with low to medium lesion load. However, for high lesion load subjects, the omission of WMLs may yield less robust local EF estimations in the vicinity of the lesioned tissue. Our results contribute to the efforts of accurate modeling of tDCS for treatment planning.

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Language(s): eng - English
 Dates: 2022-05-042022-03-052022-05-302022-06-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.nicl.2022.103071
Other: online ahead of print
PMID: 35671557
PMC: PMC9168230
 Degree: -

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 35 Sequence Number: 103071 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582