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  Genome-wide association study of musical beat synchronization demonstrates high polygenicity

Niarchou, M., Gustavson, D. E., Sathirapongsasuti, J. F., Anglada-Tort, M., Eising, E., Bell, E., et al. (2022). Genome-wide association study of musical beat synchronization demonstrates high polygenicity. Nature Human Behaviour, 6, 1292-1309. doi:10.1038/s41562-022-01359-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-9C52-A Version Permalink: https://hdl.handle.net/21.11116/0000-000B-6623-B
Genre: Journal Article

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. © The Author(s) 2022
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 Creators:
Niarchou, Maria1, 2, Author
Gustavson, Daniel E.1, 2, Author
Sathirapongsasuti, J. Fah3, Author
Anglada-Tort, Manuel4, Author           
Eising, Else5, Author
Bell, Eamonn6, 7, Author
McArthur, Evonne1, Author
Straub, Peter1, Author
The 23andMe Research Team, Author              
McAuley, J. Devin8, Author
Capra, John A.9, 10, Author
Ullén, Fredrik11, 12, Author           
Creanza, Nicole13, 14, Author
Mosing, Miriam A.11, 12, 15, Author           
Hinds, David3, Author
Davis, Lea K.1, 2, 16, 17, 18, Author
Jacoby, Nori4, Author           
Gordon, Reyna L.1, 19, 20, 21, Author
Affiliations:
1Vanderbilt Genetics Institute, Vanderbilt University Medical Center , Nashville, TN, USA, ou_persistent22              
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA, ou_persistent22              
323andMe, Inc, Sunnyvale, CA, USA, ou_persistent22              
4Research Group Computational Auditory Perception, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_3024247              
5Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
6Department of Music, Columbia University , New York, NY, USA, ou_persistent22              
7Department of Computer Science, Durham University, Durham, UK, ou_persistent22              
8Department of Psychology, Michigan State University, East Lansing, MI, USA, ou_persistent22              
9Bakar Computational Health Sciences Institute, University of California , San Francisco, CA, USA, ou_persistent22              
10Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA, ou_persistent22              
11Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_3351901              
12Department of Neuroscience, Karolinska Institutet, Solna, Sweden, ou_persistent22              
13Department of Biological Sciences, Vanderbilt University , Nashville, TN, USA, ou_persistent22              
14Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA, ou_persistent22              
15Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia, ou_persistent22              
16Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN, USA, ou_persistent22              
17Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA, ou_persistent22              
18Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA, ou_persistent22              
19Department of Otolaryngology—Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA, ou_persistent22              
20Department of Psychology, Vanderbilt University, Nashville, TN, USA, ou_persistent22              
21Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA, ou_persistent22              

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Free keywords: Cognitive neuroscience, Evolutionary genetics, Genome-wide association studies, Human behaviour
 Abstract: Moving in synchrony to the beat is a fundamental component of musicality. Here, we conducted a genome-wide association study (GWAS) to identify common genetic variants associated with beat synchronization in 606,825 individuals. Beat synchronization exhibited a highly polygenic architecture, with sixty-nine loci reaching genome-wide significance (p<5×10−8) and SNP-based heritability (on the liability scale) of 13%-16%. Heritability was enriched for genes expressed in brain tissues, and for fetal and adult brain-specific gene regulatory elements, underscoring the role of central nervous system-expressed genes linked to the genetic basis of the trait. We performed validations of the self-report phenotype (through internet-based experiments) and of the GWAS (polygenic scores for beat synchronization were associated with patients algorithmically classified as musicians in medical records of a separate biobank). Genetic correlations with breathing function, motor function, processing speed, and chronotype suggest shared genetic architecture with beat synchronization and provide avenues for new phenotypic and genetic explorations.Competing Interest StatementJFS, DH, and members of the 23andMe Research Team are employees of 23andMe, Inc., and hold stock or stock options in 23andMe. All other authors declare no competing interests.

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Language(s): eng - English
 Dates: 2021-01-092022-04-212022-06-162022-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: No review
 Identifiers: DOI: 10.1038/s41562-022-01359-x
 Degree: -

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Title: Nature Human Behaviour
Source Genre: Journal
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Publ. Info: London : Nature Research
Pages: - Volume / Issue: 6 Sequence Number: - Start / End Page: 1292 - 1309 Identifier: ISSN: 2397-3374
CoNE: https://pure.mpg.de/cone/journals/resource/2397-3374