English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  Functional DNA-based cytoskeletons for synthetic cells

Zhan, P., Jahnke, K., Liu, N., & Göpfrich, K. (2022). Functional DNA-based cytoskeletons for synthetic cells. Nature Chemistry, 1-8. doi:10.1038/s41557-022-00945-w.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000A-9D5B-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-9D5C-F
Genre: Journal Article

Files

show Files
hide Files
:
NatChem_epub_2022_945-w.pdf (Any fulltext), 3MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl1.pdf (Supplementary material), 65MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl1.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl2.xlsx (Supplementary material), 18KB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl2.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl3.mp4 (Supplementary material), 4MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl3.mp4
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/mp4
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl4.mp4 (Supplementary material), 5MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl4.mp4
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/mp4
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl5.mp4 (Supplementary material), 7MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl5.mp4
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/mp4
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl6.mp4 (Supplementary material), 5MB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl6.mp4
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/mp4
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatChem_epub_2022_945-w_Suppl7.mp4 (Supplementary material), 617KB
 
File Permalink:
-
Name:
NatChem_epub_2022_945-w_Suppl7.mp4
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/mp4
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Zhan, Pengfei, Author
Jahnke, Kevin1, Author           
Liu, Na, Author
Göpfrich, Kerstin1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

Content

show
hide
Free keywords: -
 Abstract: The cytoskeleton is an essential component of a cell. It controls the cell shape, establishes the internal organization, and performs vital biological functions. Building synthetic cytoskeletons that mimic key features of their natural counterparts delineates a crucial step towards synthetic cells assembled from the bottom up. To this end, DNA nanotechnology represents one of the most promising routes, given the inherent sequence specificity, addressability and programmability of DNA. Here we demonstrate functional DNA-based cytoskeletons operating in microfluidic cell-sized compartments. The synthetic cytoskeletons consist of DNA tiles self-assembled into filament networks. These filaments can be rationally designed and controlled to imitate features of natural cytoskeletons, including reversible assembly and ATP-triggered polymerization, and we also explore their potential for guided vesicle transport in cell-sized confinement. Also, they possess engineerable characteristics, including assembly and disassembly powered by DNA hybridization or aptamer–target interactions and autonomous transport of gold nanoparticles. This work underpins DNA nanotechnology as a key player in building synthetic cells.

Details

show
hide
Language(s): eng - English
 Dates: 2021-03-052022-04-042022-06-20
 Publication Status: Published online
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41557-022-00945-w
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Chemistry
  Abbreviation : Nat. Chem.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 8 Identifier: ISSN: 1755-4330
CoNE: https://pure.mpg.de/cone/journals/resource/1755-4330