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  Strongly enhanced toxicity of the mushroom toxin α-amanitin by an amatoxin-specific Fab or monoclonal antibody

Faulstich, H., Kirchner, K., & Derenzini, M. (1988). Strongly enhanced toxicity of the mushroom toxin α-amanitin by an amatoxin-specific Fab or monoclonal antibody. Toxicon, 26(5), 491-499. doi:10.1016/0041-0101(88)90188-2.

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Genre: Journal Article
Alternative Title : Strongly enhanced toxicity of the mushroom toxin alpha-amanitin by an amatoxin-specific Fab or monoclonal antibody

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 Creators:
Faulstich, Heinz1, Author           
Kirchner, Karin2, Author           
Derenzini, Massimo, Author
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1Department of Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_3321127              
2Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: H. Faulstich, K. Kirchiner and M. Derenzini. Strongly enhanced toxicity of the mushroom toxin α-amanitin by an amatoxin-specific Fab or monoclonal antibody. Toxicon26, 491–499, 1988. — A monoclonal antibody, with high affinity against the mushroom toxin α-amanitin, was prepared. Administration of the Fab fragment of the monoclonal antibody to mice caused a 50-fold increase in α-amanitin toxicity. Electron micrographs showed normal appearance of hepatocytes but typical, amanitin-induced lesions in cells of the proximal convoluted tubules of the kidney. The pronounced nephrotoxicity is mainly explained by glomerular filtration and tubular reabsorption of the Fab-amatoxin complex and, to a lesser extent, of the immunoglobulin — amatoxin complex, which is still c. twice as toxic as free α-amanitin. To our knowledge this is the first reported case where immunoglobulins or their fragments enhance rather than decrease the activity of a toxin. Accordingly, immunotherapy of Amanita mushroom poisoning in humans does not appear promising.

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Language(s): eng - English
 Dates: 1987-11-171988
 Publication Status: Issued
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0041-0101(88)90188-2
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Title: Toxicon
  Other : Toxicon
Source Genre: Journal
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Publ. Info: Amsterdam : Pergamon
Pages: - Volume / Issue: 26 (5) Sequence Number: - Start / End Page: 491 - 499 Identifier: ISSN: 0041-0101
CoNE: https://pure.mpg.de/cone/journals/resource/991042741145534