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  Antimicrobial diterpene alkaloids from an Agelas Citrina sponge collected in the Yucatán Peninsula

Pech-Puch, D., Forero, A. M., Fuentes-Monteverde, J. C., Lasarte-Monterrubio, C., Martinez-Guitian, M., González-Salas, C., et al. (2022). Antimicrobial diterpene alkaloids from an Agelas Citrina sponge collected in the Yucatán Peninsula. Marine Drugs, 20(5): 298. doi:10.3390/md20050298.

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Pech-Puch, D., Author
Forero, A. M., Author
Fuentes-Monteverde, J. C.1, Author           
Lasarte-Monterrubio, C., Author
Martinez-Guitian, M., Author
González-Salas, C., Author
Guillén-Hernández, S., Author
Villegas-Hernández, H., Author
Beceiro, A., Author
Griesinger, C.1, Author                 
Rodríguez, J., Author
Jiménez, C., Author
Affiliations:
1Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350124              

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Free keywords: diterpene alkaloids; agelasines; agelasidines; marine sponge; agelas citrina; antibacterial; derivatives;diversity
 Abstract: Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and (+)-agelasidine C (6), were isolated from the sponge Agelas citrina, collected on the coasts of the Yucatan Peninsula (Mexico). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, HRESIMS techniques, and a comparison with literature data. Although the synthesis of (+)-ent-agelasine F (4) has been previously reported, this is the first time that it was isolated as a natural product. The evaluation of the antimicrobial activity against the Gram-positive pathogens Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis showed that all of them were active, with (+)-10-epiagelasine B (2) being the most active compound with an MIC in the range of 1-8 mu g/mL. On the other hand, the Gram-negative pathogenes Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae were also evaluated, and only (+)-agelasine B (5) showed a moderate antibacterial activity with a MIC value of 16 mu g/mL.

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 Dates: 2022-04-28
 Publication Status: Published online
 Pages: 12
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/md20050298
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Title: Marine Drugs
Source Genre: Journal
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Pages: 12 Volume / Issue: 20 (5) Sequence Number: 298 Start / End Page: - Identifier: ISSN: 1660-3397