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  Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations

Raatz, M., & Traulsen, A. (2023). Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations. Evolution: international journal of organic evolution, 77(6), 1408-1421. doi:10.1093/evolut/qpad042.

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Genre: Zeitschriftenartikel

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externe Referenz:
https://doi.org/10.5281/zenodo.6656842 (Forschungsdaten)
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externe Referenz:
https://doi.org/10.5281/zenodo.6656847 (Forschungsdaten)
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Urheber

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 Urheber:
Raatz, Michael1, Autor           
Traulsen, Arne1, Autor                 
Affiliations:
1Department Theoretical Biology (Traulsen), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

Inhalt

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Schlagwörter: Evolutionary rescue, Resistance evolution, Dormancy, Competitive release, Immune evasion
 Zusammenfassung: When cancers or bacterial infections establish, small populations of cells have to free themselves from homoeostatic regulations that prevent their expansion. Trait evolution allows these populations to evade this regulation, escape stochastic extinction and climb up the fitness landscape. In this study, we analyse this complex process and investigate the fate of a cell population that underlies the basic processes of birth, death and mutation. We find that the shape of the fitness landscape dictates a circular adaptation trajectory in trait space. We show that successful adaptation is less likely for parental populations with higher turnover (higher birth and death rates). Including density- or trait-affecting treatment we find that these treatment types change the adaptation dynamics in agreement with geometrically derived hypotheses. Treatment strategies that simultaneously target birth and death rates are most effective, but also increase evolvability. By mapping physiological adaptation pathways and molecular drug mechanisms to traits and treatments with clear eco-evolutionary consequences, we can achieve a much better understanding of the adaptation dynamics and the eco-evolutionary mechanisms at play in the dynamics of cancer and bacterial infections.

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Sprache(n): eng - English
 Datum: 2022-06-172023-02-222023-02-032023-03-082023-03-102023-06
 Publikationsstatus: Erschienen
 Seiten: 41
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/evolut/qpad042
 Art des Abschluß: -

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Projektinformation

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Projektname : Translational Evolutionary Research (TransEvo)
Grant ID : 400993799
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)

Quelle 1

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Titel: Evolution: international journal of organic evolution
  Kurztitel : Evolution
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Wiley
Seiten: - Band / Heft: 77 (6) Artikelnummer: - Start- / Endseite: 1408 - 1421 Identifikator: ISSN: 0014-3820
CoNE: https://pure.mpg.de/cone/journals/resource/991042730870254