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  Transposable elements promote the evolution of genome streamlining

van Dijk, B., Bertels, F., Stolk, L., Takeuchi, N., & Rainey, P. B. (2022). Transposable elements promote the evolution of genome streamlining. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 377(1842): 20200477. doi:10.1098/rstb.2020.0477.

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 Creators:
van Dijk, Bram1, Author              
Bertels, Frederic2, Author              
Stolk, Lianne, Author
Takeuchi, Nobuto, Author
Rainey, Paul B.1, Author              
Affiliations:
1Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2421699              
2Research Group Microbial Molecular Evolution, Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2497692              

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Free keywords: ineage selection, non-transitive interactions,sex, horizontal gene transfer, spatial structure,altruism
 Abstract: Eukaryotes and prokaryotes have distinct genome architectures, withmarked differences in genome size, the ratio of coding/non-coding DNA,and the abundance of transposable elements (TEs). As TEs replicate inde-pendently of their hosts, the proliferation of TEs is thought to have drivengenome expansion in eukaryotes. However, prokaryotes also have TEs inintergenic spaces, so why do prokaryotes have small, streamlined genomes?Using anin silicomodel describing the genomes of single-celled asexualorganisms that coevolve with TEs, we show that TEs acquired from theenvironment by horizontal gene transfer can promote the evolution ofgenome streamlining. The process depends on local interactions and isunderpinned by rock–paper–scissors dynamics in which populations ofcells with streamlined genomes beat TEs, which beat non-streamlinedgenomes, which beat streamlined genomes, in continuous and repeatingcycles. Streamlining is maladaptive to individual cells, but improves lineageviability by hindering the proliferation of TEs. Streamlining does not evolvein sexually reproducing populations because recombination partially freesTEs from the deleterious effects they cause.This article is part of the theme issue‘The secret lives of microbial mobilegenetic elements’.

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Language(s): eng - English
 Dates: 2021-05-292021-08-302021-11-292022-01
 Publication Status: Published in print
 Pages: -
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 Identifiers: DOI: 10.1098/rstb.2020.0477
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Title: Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
  Other : Philosophical Transactions B
  Abbreviation : Phil. Trans. R. Soc. B
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: - Volume / Issue: 377 (1842) Sequence Number: 20200477 Start / End Page: - Identifier: ISSN: 0962-8436
CoNE: https://pure.mpg.de/cone/journals/resource/963017382021_1