English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Neurons as a model system for cryo-electron tomography

Zuber, B., & Lucic, V. (2022). Neurons as a model system for cryo-electron tomography. Journal of Structural Biology: X, 6: 100067. doi:10.1016/j.yjsbx.2022.100067.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Zuber, B., Author
Lucic, V.1, Author           
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

Content

show
hide
Free keywords: Neurons Synapses Electron microscopy Cryo-electron tomography electron tomography molecular architecture light-microscopy hippocampal organization synapses reveals cells microtubules complexes Biochemistry & Molecular Biology Biophysics Cell Biology
 Abstract: Cryo-electron tomography (Cryo-ET) provides unique opportunities to image cellular components at high resolution in their native state and environment. While many different cell types were investigated by cryo-ET, here we review application to neurons. We show that neurons are a versatile system that can be used to investigate general cellular components such as the cytoskeleton and membrane-bound organelles, in addition to neuron specific processes such as synaptic transmission. Furthermore, the synapse provides a rich environment for the development of cryo-ET image processing tools suitable to elucidate the functional and spatial organization of compositionally and morphologically heterogeneous macromolecular complexes involved in biochemical signaling cascades, within their native, crowded cellular environments.

Details

show
hide
Language(s): eng - English
 Dates: 2022
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000793365600004
DOI: 10.1016/j.yjsbx.2022.100067
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Structural Biology: X
  Abbreviation : JSBX
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Diego, CA : Elsevier
Pages: - Volume / Issue: 6 Sequence Number: 100067 Start / End Page: - Identifier: ISSN: 2590-1524
CoNE: https://pure.mpg.de/cone/journals/resource/2590-1524