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  AGO1 affects the virulence of the fungal plant pathogen Zymoseptoria tritici

Habig, M., Schotanus, K., Hufnagel, K., Happel, P., & Stukenbrock, E. H. (2021). AGO1 affects the virulence of the fungal plant pathogen Zymoseptoria tritici. Genes (Basel), 12(7). doi:10.3390/genes12071011.

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 Creators:
Habig, Michael, Author
Schotanus, Klaas, Author
Hufnagel, Kim, Author
Happel, Petra1, 2, Author           
Stukenbrock, Eva H., Author
Affiliations:
1Department of Organismic Interactions, Alumni, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266313              
2Max Planck Institute for Terrestrial Microbiology, Max Planck Society, Karl-von-Frisch-Strasse 10, D-35043 Marburg, DE, ou_3135468              

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Free keywords: Argonaute Proteins/antagonists & inhibitors/genetics/*metabolism Ascomycota/*physiology *Chromosomal Instability *Host-Pathogen Interactions Plant Diseases/*genetics RNA Interference Triticum/genetics/metabolism/*microbiology *Virulence *RNA interference *chromosome biology *pathogenicity
 Abstract: In host-pathogen interactions RNA interference (RNAi) has emerged as a pivotal mechanism to modify both, the immune responses of the host as well as the pathogenicity and virulence of the pathogen. In addition, in some fungi RNAi is also known to affect chromosome biology via its effect on chromatin conformation. Previous studies reported no effect of the RNAi machinery on the virulence of the fungal plant pathogen Zymoseptoria tritici however the role of RNAi is still poorly understood in this species. Herein, we elucidate whether the RNAi machinery is conserved within the genus Zymoseptoria. Moreover, we conduct functional analyses of Argonaute and Dicer-like proteins and test if the RNAi machinery affects chromosome stability. We show that the RNAi machinery is conserved among closely related Zymoseptoria species while an exceptional pattern of allelic diversity was possibly caused by introgression. The deletion of Ago1 reduced the ability of the fungus to produce asexual propagules in planta in a quantitative matter. Chromosome stability of the accessory chromosome of Z. tritici was not prominently affected by the RNAi machinery. These results indicate, in contrast to previous finding, a role of the RNAi pathway during host infection, but not in the stability of accessory chromosomes in Z. tritici.

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Language(s): eng - English
 Dates: 2021-07-03
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 34208898
DOI: 10.3390/genes12071011
ISSN: 2073-4425
 Degree: -

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Title: Genes (Basel)
Source Genre: Journal
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Pages: - Volume / Issue: 12 (7) Sequence Number: - Start / End Page: - Identifier: -