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  Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)

Walther, A., Mackens-Kiani, A., Eder, J., Herbig, M., Herold, C., Kirschbaum, C., et al. (2022). Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph). Translational Psychiatry, 12: 150. doi:10.1038/s41398-022-01911-3.

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Transl Psychiatry 2022 Walther.pdf (Publisher version), 2MB
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

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 Creators:
Walther, Andreas1, 2, Author
Mackens-Kiani, Anne1, Author
Eder, Julian1, Author
Herbig, Maik1, 3, Author
Herold, Christoph1, 2, Author
Kirschbaum, Clemens1, Author
Guck, Jochen3, 4, Author           
Wittwer, Lucas2, 3, Author
Beesdo-Baum, Katja1, Author
Kräter, Martin3, Author           
Affiliations:
1Technische Universität Dresden, ou_persistent22              
2external, ou_persistent22              
3Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
4Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              

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 Abstract: Pathophysiological landmarks of depressive disorders are chronic low-grade inflammation and elevated glucocorticoid output. Both can potentially interfere with cytoskeleton organization, cell membrane bending and cell function, suggesting altered cell morpho-rheological properties like cell deformability and other cell mechanical features in depressive disorders. We performed a cross-sectional case-control study using the image-based morpho-rheological characterization of unmanipulated blood samples facilitating real-time deformability cytometry (RT-DC). Sixty-nine pre-screened individuals at high risk for depressive disorders and 70 matched healthy controls were included and clinically evaluated by Composite International Diagnostic Interview leading to lifetime and 12-month diagnoses. Facilitating deep learning on blood cell images, major blood cell types were classified and morpho-rheological parameters such as cell size and cell deformability of every individual cell was quantified. We found peripheral blood cells to be more deformable in patients with depressive disorders compared to controls, while cell size was not affected. Lifetime persistent depressive disorder was associated with increased cell deformability in monocytes and neutrophils, while in 12-month persistent depressive disorder erythrocytes deformed more. Lymphocytes were more deformable in 12-month major depressive disorder, while for lifetime major depressive disorder no differences could be identified. After correction for multiple testing, only associations for lifetime persistent depressive disorder remained significant. This is the first study analyzing morpho-rheological properties of entire blood cells and highlighting depressive disorders and in particular persistent depressive disorders to be associated with increased blood cell deformability. While all major blood cells tend to be more deformable, lymphocytes, monocytes, and neutrophils are mostly affected. This indicates that immune cell mechanical changes occur in depressive disorders, which might be predictive of persistent immune response.

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Language(s): eng - English
 Dates: 2022-03-222022-04-08
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1038/s41398-022-01911-3
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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 12 Sequence Number: 150 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188