ausblenden:
Schlagwörter:
Action Potentials/*physiology
Algorithms
Animals
Biological Clocks/*physiology
*Cortical Synchronization
Electrodes, Implanted
Electrophysiology/instrumentation/methods
Macaca mulatta
Neuronal Plasticity/physiology
Neurons/*physiology
*Periodicity
Photic Stimulation
Signal Processing, Computer-Assisted
Synaptic Transmission/physiology
Visual Cortex/anatomy & histology/*physiology
Visual Pathways/physiology
Visual Perception/physiology
Wakefulness/physiology
Zusammenfassung:
Gamma-band synchronization is abundant in nervous systems. Typically, the strength or precision of gamma-band synchronization is studied. However, the precise phase with which individual neurons are synchronized to the gamma-band rhythm might have interesting consequences for their impact on further processing and for spike timing-dependent plasticity. Therefore, we investigated whether the spike times of individual neurons shift systematically in the gamma cycle as a function of the neuronal activation strength. We found that stronger neuronal activation leads to spikes earlier in the gamma cycle, i.e., we observed gamma-phase shifting. Gamma-phase shifting occurred on very rapid timescales. It was particularly pronounced for periods in which gamma-band synchronization was relatively weak and for neurons that were only weakly coupled to the gamma rhythm. We suggest that gamma-phase shifting is brought about by an interplay between overall excitation and gamma-rhythmic synaptic input and has interesting consequences for neuronal coding, competition, and plasticity.
