Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Differential diagnosis between Alzheimer’s disease-related depression and pseudo-dementia in depression: A new indication for amyloid-β imaging?

Leonhardi, J., Barthel, H., Speerforck, S., Dietzel, J., Schroeter, M. L., Saur, D., et al. (2022). Differential diagnosis between Alzheimer’s disease-related depression and pseudo-dementia in depression: A new indication for amyloid-β imaging? Journal of Alzheimer's Disease, 88(3), 1029-1035. doi:10.3233/JAD-215619.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Leonhardi, Jakob1, 2, Autor
Barthel, Henryk1, Autor
Speerforck, Sven3, Autor
Dietzel, Jens3, Autor
Schroeter, Matthias L.4, 5, Autor           
Saur, Dorothee6, Autor
Tiepolt, Solveig1, Autor
Rullmann, Michael1, Autor
Patt, Marianne1, Autor
Claßen, Joseph6, Autor
Schomerus, Georg3, Autor
Sabri, Osama1, Autor
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department of Neurology, University Hospital Leipzig, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Alzheimer’s disease; [18F]florbetaben; Amyloid PET imaging; Amyloid-β; Depression; Mild cognitive impairment; Pittsburgh compound B; Pseudo-dementia
 Zusammenfassung: Background: Alzheimer's disease and depression can start with combined cognitive and depressive symptoms [1, 2]. Accurate differential diagnosis is desired to initiate specific treatment.

Objective: We investigated whether amyloid-β PET imaging can discriminate both entities.

Methods: This retrospective observational study included 39 patients (20 female, age = 70±11years) with both cognitive and depressive symptoms who underwent amyloid-β PET imaging and in whom clinical follow-up data was available. Amyloid-β PET was carried out applying [18F]Florbetaben or [11C]PiB. The PET images were analyzed by standardized visual and relative-quantitative evaluation. Based on clinical follow-up (median of 2.4 years [range 0.3 to 7.0 years, IQR = 3.7 years] after amyloid PET imaging which was not considered in obtaining a definite diagnosis), discrimination ability between AD-related depression and pseudo-dementia in depression/depression with other comorbidities was determined.

Results: Visually, all 10 patients with pseudo-dementia in depression and all 15 patients with other depression were rated as amyloid-β-negative; 2 of 14 patients with AD-related depression were rated amyloid-β-negative. ROC curve analysis of the unified composite standardized uptake value ratios (cSUVRs) was able to discriminate pseudo-dementia in depression from AD-related depression with high accuracy (AUC = 0.92). Optimal [18F]Florbetaben discrimination cSUVR threshold was 1.34. In congruence with the visual PET analysis, the resulting sensitivity of the relative-quantitative analysis was 86% with a specificity of 100% .

Conclusion: Amyloid-β PET can differentiate AD-related depression and pseudo-dementia in depression. Prospective clinical studies are warranted to confirm this result and to potentially broaden the spectrum of clinical applications for amyloid-β PET imaging.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2022-05-162022-06-132022
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3233/JAD-215619
PMID: 35723098
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Alzheimer's Disease
  Kurztitel : J. Alzheimers Dis.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : IOS Press
Seiten: - Band / Heft: 88 (3) Artikelnummer: - Start- / Endseite: 1029 - 1035 Identifikator: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877