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  Longitudinal changes of ADHD symptoms in association with white matter microstructure: A tract-specific fixel-based analysis

Damatac, C. G., Soheili-Nezhad, S., Blazquez Freches, G., Zwiers, M. P., De Bruijn, S., Ikde, S., et al. (2022). Longitudinal changes of ADHD symptoms in association with white matter microstructure: A tract-specific fixel-based analysis. NeuroImage: Clinical, 35: 103057. doi:10.1016/j.nicl.2022.103057.

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 Creators:
Damatac, Christienne G., Author
Soheili-Nezhad, Sourena1, Author           
Blazquez Freches, Guilherme, Author
Zwiers, Marcel P., Author
De Bruijn, Sanne, Author
Ikde, Seyma, Author
Portengen, Christel M., Author
Abelmann, Amy C., Author
Dammers, Janneke T., Author
Van Rooij, Daan, Author
Akkermans, Sophie E.A., Author
Naaijen, Jilly, Author
Franke, Barbara, Author
Buitelaar, Jan K., Author
Beckmann, Christian F., Author
Sprooten, Emma, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              

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 Abstract: Background

Variation in the longitudinal course of childhood attention deficit/hyperactivity disorder (ADHD) coincides with neurodevelopmental maturation of brain structure and function. Prior work has attempted to determine how alterations in white matter (WM) relate to changes in symptom severity, but much of that work has been done in smaller cross-sectional samples using voxel-based analyses. Using standard diffusion-weighted imaging (DWI) methods, we previously showed WM alterations were associated with ADHD symptom remission over time in a longitudinal sample of probands, siblings, and unaffected individuals. Here, we extend this work by further assessing the nature of these changes in WM microstructure by including an additional follow-up measurement (aged 18 – 34 years), and using the more physiologically informative fixel-based analysis (FBA).
Methods

Data were obtained from 139 participants over 3 clinical and 2 follow-up DWI waves, and analyzed using FBA in regions-of-interest based on prior findings. We replicated previously reported significant models and extended them by adding another time-point, testing whether changes in combined ADHD and hyperactivity-impulsivity (HI) continuous symptom scores are associated with fixel metrics at follow-up.
Results

Clinical improvement in HI symptoms over time was associated with more fiber density at follow-up in the left corticospinal tract (lCST) (tmax = 1.092, standardized effect[SE] = 0.044, pFWE = 0.016). Improvement in combined ADHD symptoms over time was associated with more fiber cross-section at follow-up in the lCST (tmax = 3.775, SE = 0.051, pFWE = 0.019).
Conclusions

Aberrant white matter development involves both lCST micro- and macrostructural alterations, and its path may be moderated by preceding symptom trajectory.

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Language(s): eng - English
 Dates: 2022
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nicl.2022.103057
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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 35 Sequence Number: 103057 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582