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  Mnemonic construction and representation of temporal structure in the hippocampal formation

Bellmund, J. L. S., Deuker, L., Montijn, N. D., & Doeller, C. F. (2022). Mnemonic construction and representation of temporal structure in the hippocampal formation. Nature Communications, 13(1): 3395. doi:10.1038/s41467-022-30984-3.

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 Creators:
Bellmund, Jacob L. S.1, Author           
Deuker, Lorena2, Author
Montijn, Nicole D.3, Author
Doeller, Christian F.1, 4, 5, Author           
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Clinical Psychology, Utrecht University, the Netherlands, ou_persistent22              
4Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
5Institute of Psychology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cognitive neuroscience; Psychology
 Abstract: The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.

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Language(s): eng - English
 Dates: 2021-07-152022-05-202022-06-23
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41467-022-30984-3
PMID: 35739096
PMC: PMC9226117
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 13 (1) Sequence Number: 3395 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723