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  The role of GW182 proteins in miRNA-mediated gene silencing

Braun, J., Huntzinger, E., & Izaurralde, E. (2013). The role of GW182 proteins in miRNA-mediated gene silencing. In Advances in Experimental Medicine and Biology. New York: Plenum Press.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-AEA4-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-AEA5-8
Genre: Book Chapter

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 Creators:
Braun, JE1, Author           
Huntzinger, E1, Author           
Izaurralde, E1, Author           
Affiliations:
1Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375718              

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 Abstract: GW182 family proteins are essential for microRNA-mediated gene silencing in animal cells. They are recruited to miRNA targets through direct interactions with Argonaute proteins and promote target silencing. They do so by repressing translation and enhancing mRNA turnover. Although the precise mechanism of action of GW182 proteins is not fully understood, these proteins have been shown to interact with the cytoplasmic poly(A)-binding protein (PABP) and with the PAN2-PAN3 and CCR4-NOT deadenylase complexes. These findings suggest that GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets.

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 Dates: 2013
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/978-1-4614-5107-5_9
PMID: 23224969
 Degree: -

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Title: Advances in Experimental Medicine and Biology
  Other : Advances in Experimental Medicine and Biology
Source Genre: Series
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Publ. Info: New York : Plenum Press
Pages: - Volume / Issue: 768 Sequence Number: - Start / End Page: - Identifier: ISSN: 0065-2598
CoNE: https://pure.mpg.de/cone/journals/resource/954927588283_1

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Title: Ten Years of Progress in GW/P Body Research
Source Genre: Book
 Creator(s):
Chan, EKL, Editor
Fritzler, MJ, Editor
Affiliations:
-
Publ. Info: New York, NY, USA : Springer
Pages: 276 Volume / Issue: - Sequence Number: - Start / End Page: 147 - 163 Identifier: ISBN: 978-1-4614-5106-8
DOI: 10.1007/978-1-4614-5107-5