English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Synthesis of oligosaccharide antigens as glycoconjugate vaccine candidates against bacterial pathogens

Zhang, S. (2022). Synthesis of oligosaccharide antigens as glycoconjugate vaccine candidates against bacterial pathogens. PhD Thesis, Freie Universität, Berlin.

Item is

Files

show Files
hide Files
:
Thesis.pdf (Any fulltext), 8MB
Name:
Thesis.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Zhang, Shuo1, Author           
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

Content

show
hide
Free keywords: -
 Abstract: Capsular polysaccharides (CPSs) from the bacterial cell surface are important virulence factors and play an essential role for bacterial survival. CPSs are also important antigens capable of inducing a specific immune response rending these structurally unique glycans attractive targets for antibacterial vaccines development. The first part of the dissertation describes the construction of a collection of 15 novel synthetic oligosaccharides resembling the capsular polysaccharides of Streptococcus suis serotype 9. Differently protected monosaccharide building blocks were synthesized and employed into glycosylations to assemble the oligosaccharides. The second part of the dissertation focused on a multi-drug resistant bacterium Acinetobacter baumannii. The synthesis of repeating unit of CPS from A. baumannii AB5075 as well as two analogues is described. The synthetic oligosaccharides bearing an amine linker are ready for glycan microarray study, identification of the minimal epitope and conjugation.

Details

show
hide
Language(s): eng - English
 Dates: 2022
 Publication Status: Accepted / In Press
 Pages: XII, 186 Seiten
 Publishing info: Berlin : Freie Universität
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.17169/refubium-33658
 Degree: PhD

Event

show

Legal Case

show

Project information

show

Source

show