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  The Good and the Bad of Mitochondrial Breakups

Sprenger, H.-G., & Langer, T. (2019). The Good and the Bad of Mitochondrial Breakups. Trends Cell Biol, 29(11), 888-900. doi:10.1016/j.tcb.2019.08.003.

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 Creators:
Sprenger, Hans-Georg1, Author           
Langer, T.2, Author           
Affiliations:
1Sprenger – Molecular Metabolism & Energy Homeostasis, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3583700              
2Department Langer - Mitochondrial Proteostasis, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3393994              

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Free keywords: Animals Cell Death/physiology Cell Division/physiology Cell Survival/physiology Humans Mitochondria/*metabolism Mitochondrial Dynamics/*physiology Mitophagy/*physiology *metabolism *mitochondrial dynamics *mitochondrial fission *mitochondrial fragmentation *mitochondrial fusion *mitochondrial quality control
 Abstract: Mitochondrial morphology is a crucial determinant of mitochondrial and cellular function. Opposing fusion and fission events shape the tubular mitochondrial reticulum and ensure mitochondrial transport within cells. Cellular stress and pathophysiological conditions can lead to fragmentation of the mitochondrial network, which facilitates mitophagy and is associated with cell death. However, mitochondrial shape changes are also intertwined with the cellular metabolism, and metabolic switches can induce but also result from alterations in mitochondrial morphology. Here, we discuss recent advances in the field of mitochondrial dynamics, demonstrating cell- and tissue-specific effects of mitochondrial fragmentation on cellular metabolism, cell survival, and mitochondrial quality control.

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 Dates: 2019-09-052019-09-05
 Publication Status: Issued
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 Identifiers: Other: 31495461
DOI: 10.1016/j.tcb.2019.08.003
ISSN: 1879-3088 (Electronic)0962-8924 (Linking)
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Title: Trends Cell Biol
Source Genre: Journal
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Pages: - Volume / Issue: 29 (11) Sequence Number: - Start / End Page: 888 - 900 Identifier: -