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  Common genetic associations between age-related diseases

Donertas, H. M., Fabian, D. K., Valenzuela, M. F., Partridge, L., & Thornton, J. M. (2021). Common genetic associations between age-related diseases. Nat Aging, 1(4), 400-412. doi:10.1038/s43587-021-00051-5.

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Donertas, H. M., Author
Fabian, D. K., Author
Valenzuela, M. F., Author
Partridge, L.1, Author           
Thornton, J. M., Author
Affiliations:
1Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942287              

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Free keywords: Aging Gwas UK Biobank age-related disease antagonistic pleiotropy mutation accumulation
 Abstract: Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified 4 disease clusters from 116 diseases in the UK Biobank data, defined by their age-of-onset profiles, and found that diseases with the same onset profile are genetically more similar, suggesting a common etiology. This similarity was not explained by disease categories, co-occurrences or disease cause-effect relationships. Two of the four disease clusters had an increased risk of occurrence from age 20 and 40 years respectively. They both showed an association with known aging-related genes, yet differed in functional enrichment and evolutionary profiles. Moreover, they both had age-related expression and methylation changes. We also tested mutation accumulation and antagonistic pleiotropy theories of aging and found support for both.

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 Dates: 2021-05-082021-05-08
 Publication Status: Issued
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 Identifiers: Other: 33959723
DOI: 10.1038/s43587-021-00051-5
ISSN: 2662-8465 (Electronic)2662-8465 (Linking)
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Title: Nat Aging
Source Genre: Journal
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Pages: - Volume / Issue: 1 (4) Sequence Number: - Start / End Page: 400 - 412 Identifier: -