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  Contact and competition between mitochondria and microbes

Medeiros, T. C., Mehra, C., & Pernas, L. (2021). Contact and competition between mitochondria and microbes. Curr Opin Microbiol, 63, 189-194. doi:10.1016/j.mib.2021.07.014.

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Medeiros, T C1, Author           
Mehra, C.1, Author           
Pernas, L.1, Author           
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1Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394005              

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 Abstract: Invading microbes occupy the host cytosol and take up nutrients on which host organelles are also dependent. Thus, host organelles are poised to interact with intracellular microbes. Despite the essential role of host mitochondria in cellular metabolic homeostasis and in mediating cellular responses to microbial infection, we know little of how these organelles interact with intracellular pathogens, and how such interactions affect disease pathogenesis. Here, we give an overview of the different classes of physical and metabolic interactions reported to occur between mitochondria and eukaryotic pathogens. Investigating the underlying molecular mechanisms and functions of such interactions will reveal novel aspects of infection biology.

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 Dates: 2021-08-202021-08-20
 Publication Status: Issued
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 Identifiers: Other: 34411806
DOI: 10.1016/j.mib.2021.07.014
ISSN: 1879-0364 (Electronic)1369-5274 (Linking)
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Title: Curr Opin Microbiol
Source Genre: Journal
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Pages: - Volume / Issue: 63 Sequence Number: - Start / End Page: 189 - 194 Identifier: -