ausblenden:
Schlagwörter:
Grasp55
Golgi
Tuberous Sclerosis Complex (TSC)
cellular stress response
mTORC1
rapamycin
unconventional protein secretion (UPS)
Zusammenfassung:
Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.
