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  N1-acetylspermidine is a determinant of hair follicle stem cell fate

Allmeroth, K., Kim, C. S., Annibal, A., Pouikli, A., Koester, J., Derisbourg, M. J., et al. (2021). N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci, 9(134), jcs252767. doi:10.1242/jcs.252767.

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Genre: Zeitschriftenartikel

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https://www.ncbi.nlm.nih.gov/pubmed/33973637 (beliebiger Volltext)
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Allmeroth, K.1, Autor           
Kim, C. S.1, Autor           
Annibal, A.2, Autor           
Pouikli, A.3, Autor           
Koester, J.4, Autor           
Derisbourg, M. J.1, Autor           
Chacón-Martínez, C. A.4, Autor           
Latza, C.2, Autor           
Annibal, A.2, Autor           
Tessarz, P.3, Autor           
Wickström, S. A.4, Autor           
Denzel, M.1, Autor           
Affiliations:
1Denzel – Metabolic and Genetic Regulation of Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394008              
2Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, DE, ou_1942285              
3Tessarz – Chromatin and Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942296              
4Wickström – Skin Homeostasis and Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942298              

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Schlagwörter: Cell fate Hair follicle stem cells Polyamines mRNA translation
 Zusammenfassung: Stem cell differentiation is accompanied by increased mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure. Here, we investigate the function of polyamines in stem cell fate decisions using hair follicle stem cell (HFSC) organoids. Compared to progenitor cells, HFSCs showed lower translation rates, correlating with reduced polyamine levels. Surprisingly, overall polyamine depletion decreased translation but did not affect cell fate. In contrast, specific depletion of natural polyamines mediated by spermidine/spermine N1-acetyltransferase (SSAT; also known as SAT1) activation did not reduce translation but enhanced stemness. These results suggest a translation-independent role of polyamines in cell fate regulation. Indeed, we identified N1-acetylspermidine as a determinant of cell fate that acted through increasing self-renewal, and observed elevated N1-acetylspermidine levels upon depilation-mediated HFSC proliferation and differentiation in vivo. Overall, this study delineates the diverse routes of polyamine metabolism-mediated regulation of stem cell fate decisions. This article has an associated First Person interview with the first author of the paper.

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 Datum: 2021-05-122021-05-12
 Publikationsstatus: Erschienen
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 Identifikatoren: Anderer: 33973637
DOI: 10.1242/jcs.252767
ISSN: 1477-9137 (Electronic)0021-9533 (Linking)
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Titel: J Cell Sci
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 9 (134) Artikelnummer: - Start- / Endseite: jcs252767 Identifikator: -